AMP1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
AMP1 antibody; COP2 antibody; HPT antibody; MFO1 antibody; PT antibody; At3g54720 antibody; T5N23_80 antibody; Probable glutamate carboxypeptidase AMP1 antibody; EC 3.4.17.21 antibody; Probable glutamate carboxypeptidase 2 antibody; Probable glutamate carboxypeptidase II antibody; Protein ALTERED MERISTEM PROGRAM 1 antibody; AtAMP1 antibody; Protein CONSTITUTIVE MORPHOGENESIS 2 antibody; Protein HAUPTLING antibody; Protein MULTIFOLIA antibody; Protein PRIMORDIA TIMING antibody
Target Names
AMP1
Uniprot No.
Target Background
Function
AMP1 is a protein that may modulate the levels of various small signaling molecules that regulate meristem function. It potentially plays a role in balancing and restricting the meristem-promoting activity of auxin signaling. Additionally, AMP1 is involved in the ethylene and gibberellin (GA) signaling pathways or in a parallel pathway controlling cell and hypocotyl elongation and cellular organization. It also participates in the abscisic acid (ABA) signaling pathway. AMP1 acts as a negative regulator in ABA-mediated seed germination and seedling development. It collaborates with LAMP1 to suppress ectopic stem cell niche formation in the shoot apical meristem (SAM) independently of the cytokinin signaling pathway. AMP1 modulates responses to ABA, oxidative stress, and abiotic stress. It serves as a negative regulator of the ABA signaling pathway to modulate freezing and drought stress responses. Further, it mediates carbon and amino acid metabolism. AMP1 may be involved in the acquisition and/or maintenance of seed dormancy and is involved in the regulation of response to heat shock and plant defense.
Gene References Into Functions
- Hyperphyllin-treated wild-type plants exhibited AMP1-related tissue-specific changes in various marker genes and a significant transcriptomic overlap with the mutant. PMID: 27208298
- Perturbation of CK- and ABA-related events by AMP1 mutation led to aberrant developmental phenotype and conflicting responses against abiotic and biotic stresses in Arabidopsis. PMID: 27743891
- De novo formation of supernumerary stem cell pools was enhanced in plants mutated in both AMP1 and its paralog LIKE AMP1, indicating that they exhibit partially overlapping roles to suppress stem cell niche respecification in the peripheral zone. PMID: 25673776
- Loss of ALTERED MERISTEM PROGRAM 1 function results in supernumerary egg cells at the expense of synergids, enabling the generation of dizygotic twins. If twin embryos are formed, endosperm formation is prevented, eventually resulting in ovule abortion. PMID: 25544612
- AMP1 mediates abscisic acid, oxidative, and abiotic stress responses and is involved in carbon and amino acid metabolism in Arabidopsis. PMID: 23621575
- Reports suggest that ALTERED MERISTEM PROGRAM1 (AMP1), a gene impacting multiple developmental processes in Arabidopsis via an unknown mechanism, and its paralog LIKE AMP1 (LAMP1, At5g19740) mediate the translation inhibition, but not the RNA cleavage activity, of plant miRNAs. PMID: 23622241
- There are accession-specific effects of mutations in AMP1. PMID: 21637772
- Auxin-derived positional information through MP carves out meristematic niches by locally overcoming a general differentiation-promoting activity involving AMP1. PMID: 17553903
- The mfo1 mutant produces more leaves than the wild type and bolts at the same time as the wild type. The gene was cloned and found to encode a putative glutamate carboxypeptidase, the previously reported AMP1 gene. PMID: 19597310
Database Links
Protein Families
Peptidase M28 family, M28B subfamily
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Tissue Specificity
Expressed in all plant parts. Highest levels in the bolt stem, inflorescence, root and silique. Low level in leaves.
Q&A
FAQs for Researchers on AMP1 Antibody in Academic Research
Advanced Research Questions
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How do correlates of protection (CoPs) for AMP1 differ between neutralization-dependent and Fc-mediated mechanisms?
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Neutralization-dependent CoPs: Link serum antibody concentration to IC80/IC50 values against circulating strains.
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Fc-mediated CoPs: Measure antibody-dependent cellular cytotoxicity (ADCC) activity against infected cells.
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Example findings from AMP trials :
CoP Type Threshold for Protection Neutralization (IC80) ≥ 80% inhibition ADCC activity ≥ 50% target cell lysis
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How should researchers resolve contradictions in AMP1 efficacy data across viral clades?
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What methodologies optimize AMP1’s manufacturability for clinical translation?
Methodological Guidance for Key Challenges
Addressing Viral Diversity:
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Use deep sequencing to track envelope (Env) evolution in breakthrough infections .
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Prioritize antibodies with breadth across tier 2/3 viruses in preclinical screens .
Enhancing Assay Reproducibility:
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Standardize neutralization assays using WHO reference panels.
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Include internal controls for Fc function assays (e.g., CD16-binding kinetics) .
Interpreting Negative Efficacy Data:
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Conduct post hoc analyses to identify subgroups with partial efficacy (e.g., high-risk populations).
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Compare AMP1’s neutralization breadth to next-generation bnAbs (e.g., CAP256-VRC26) .
Key Data from AMP Trials
| Parameter | 10 mg/kg Group | 30 mg/kg Group |
|---|---|---|
| Median Serum Half-life | 21 days | 28 days |
| Prevention Efficacy (PE) | 25% | 40% |
| IC80 Coverage | 30% of strains | 65% of strains |
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