GDH1 Antibody

Introduction to GDH1 Antibody

GDH1 Antibody is a polyclonal or monoclonal immunoglobulin designed to detect glutamate dehydrogenase 1 (GDH1), a mitochondrial enzyme critical for glutamine metabolism, redox homeostasis, and cancer progression. GDH1 catalyzes the reversible conversion of glutamate to α-ketoglutarate (α-KG), a key intermediate in the tricarboxylic acid (TCA) cycle. Its dysregulation is implicated in various cancers, including colorectal, hepatocellular, and renal carcinomas. GDH1 Antibody is essential for studying GDH1’s role in disease mechanisms, enabling detection via immunohistochemistry (IHC), Western blot, and other immunoassays .

Key Applications in Research

GDH1 Antibody is widely used to investigate GDH1’s functional roles in:

GDH1 Antibody has been pivotal in linking GDH1 to cancer cell proliferation, hypoxia adaptation, and metabolic stress responses .

GDH1 in Cancer Metabolism

• Role in Glutaminolysis: GDH1 drives α-KG production, sustaining TCA cycle flux under glucose deprivation. Knockdown reduces cancer cell proliferation and tumor growth .

• Redox Homeostasis: GDH1 regulates glutathione peroxidase (GPx1) activity, mitigating oxidative stress. Inhibition of GDH1 elevates ROS, impairing cancer cell survival .

Clinical Biomarker Potential

• Hypoxia-Modified GDH1: Acetylation at K503/527 in colorectal cancer correlates with disease progression and may serve as a therapeutic target .

• Prognostic Value: In renal cancer, stage-dependent GDH1 expression inversely correlates with survival, suggesting its utility in stratifying treatment .