GDPD1 Antibody

Performance Across Applications

Antigen retrieval with TE buffer (pH 9.0) or citrate buffer (pH 6.0) is recommended for optimal IHC results .

Enzymatic Functions

GDPD1 catalyzes:

• Hydrolysis of lysoglycerophospholipids (e.g., lyso-PAF, lyso-PE, lyso-PC) to lysophosphatidic acid (LPA)

• Biosynthesis of N-acylethanolamines from N-acyl-lysophospholipids

Tissue Distribution & Pathological Relevance

• High expression: Testis (human/mouse/rat), ovary (mouse), small intestine

• Clinical association: Prognostic marker in hepatocellular carcinoma (HCC)

• Regulatory role: Modulates choline phospholipid metabolism in cancer cells

Key Studies Using GDPD1 Antibody

1. Cancer Metabolism (2023):

   • GDPD1 overexpression correlated with altered phospholipid profiles in ER− breast cancers .

   • Demonstrated functional links between GDPD1 and malignant choline metabolite ratios (PC/GPC) .

2. Toxicology Studies (2025):

   • 2,3,7,8-Tetrachlorodibenzodioxin exposure upregulated GDPD1 mRNA in rodent models .

   • Acrylamide and lactic acid modulated GDPD1 expression in renal cells .

Protocol Considerations

Standard protocols and product-specific workflows are available through commercial providers .