GEM Antibody

Introduction to GEM Antibody

The GEM antibody refers to immunological reagents designed to target the GTP-binding protein overexpressed in skeletal muscle (GEM), a 33.9 kDa protein encoded by the GEM gene (OMIM: 600164). These antibodies are critical tools in studying GEM’s role in cellular processes, including cytoskeleton dynamics, mitosis, and pathologies such as cancer and viral infections.

Applications and Research Findings

GEM antibodies are utilized in:

• Immunohistochemistry (IHC): Detecting GEM expression in tissue sections (e.g., lung, cancer tissues) .

• Western Blot (WB): Analyzing GEM protein levels in cell lysates .

• ELISA/Sandwich ELISA: Quantifying GEM in biological samples (detection limit: ~0.3 ng/ml for recombinant GST-tagged GEM) .

Key Research Insights:

• Cancer Research: GEM overexpression correlates with cell invasiveness, suggesting therapeutic targeting potential .

• Viral Pathogenesis: GEM mediates HTLV-1 transmission, highlighting its role in viral biology .

Comparative Analysis of Antibody Performance

Clinical and Therapeutic Potential

While no GEM-targeting antibodies are currently in clinical trials, preclinical studies highlight potential avenues:

• Cancer Therapy: GEM’s association with cell invasiveness suggests it may serve as a biomarker or therapeutic target .

• Viral Transmission: Anti-GEM antibodies could disrupt HTLV-1 spread, though further in vivo validation is needed .