GGPPS2 Antibody
Description
Cancer Therapeutics
GGPPS2 inhibition has emerged as a strategy to disrupt protein prenylation in malignancies:
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In osteosarcoma (OS) and Ewing sarcoma (ES), GGPPS inhibitors like RAM2061 induce unfolded protein response (UPR) and apoptosis, reducing tumor growth in vivo .
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DGBP, a bisphosphonate targeting GGDPS (closely related to GGPPS), shows potent pro-apoptotic effects in T-cell leukemia by activating caspases and ERK signaling .
Inflammatory Disorders
GGPPS2 expression modulates immune responses:
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Myeloid-specific GGPPS knockout in mice exacerbates LPS-induced acute lung injury (ALI) by enhancing Rac1/NF-κB signaling in macrophages .
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In contrast, epithelial GGPPS deletion reduces lung injury, highlighting cell-type-specific roles .
Plant Biology
GGPPS2 regulates secondary metabolism in plants:
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In wintersweet (Chimonanthus praecox), CpGGPPS2 interacts with small subunit proteins (CpGPPS.SSU1/2) to influence monoterpene biosynthesis .
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Tomato GGPPS2 (SlG2) localizes to plastids and contributes to isoprenoid precursor synthesis .
Mechanistic Insights
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Enzyme Activity Modulation: Snapdragon GPPS.SSU overexpression in tobacco increases GPPS activity by 6–8 fold while suppressing GGPPS activity, demonstrating isoform cross-regulation .
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Structural Determinants: The methionine residue upstream of the FARM motif is critical for GGPP synthesis in GGPPS2 homologs .
Therapeutic Implications
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Apoptosis Induction: GGPPS2 inhibition depletes GGPP pools, leading to defective small GTPase prenylation and caspase-mediated apoptosis in leukemia cells .
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Metabolic Reprogramming: GGPPS2-deficient macrophages exhibit altered cholesterol synthesis and increased pro-inflammatory cytokine secretion .
Challenges and Future Directions
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
