GLR2.5 Antibody

Potential Reference to TLR2-Targeting Antibodies

The designation "GLR2.5" may represent a typographical error or nomenclature variant for TLR2-specific antibodies, such as the monoclonal antibody T2.5 described in Search Result . This antibody directly targets Toll-like receptor 2 (TLR2), a key mediator of innate immune responses to bacterial pathogens.

Key Functional Data for Anti-TLR2 Antibody T2.5:

This antibody demonstrates dose-dependent neutralization of TLR2 signaling, with 40 mg/kg conferring survival benefits in murine sepsis models .

Relation to GLUR2/GRIA2 Antibodies

If "GLR2.5" refers to GLUR2/GRIA2-targeting antibodies, Search Results provide detailed characterizations of monoclonal and polyclonal antibodies against this AMPA glutamate receptor subunit.

Research Gaps and Ambiguities

• Nomenclature Conflicts: No publications explicitly use "GLR2.5" as a standardized identifier.

• Functional Overlaps: Antibodies targeting TLR2 and GLUR2/GRIA2 operate in distinct biological contexts (immune response vs. neuronal signaling).

• Therapeutic Potential: TLR2 antibodies like T2.5 show promise in sepsis , while GLUR2 antibodies are tools for neurodegenerative disease research .

Recommendations for Further Investigation

To resolve ambiguities:

1. Validate the intended target (TLR2 vs. GLUR2/GRIA2).

2. Cross-reference antibody clones/catalogs (e.g., CAB11316, T2.5) with proprietary databases.

3. Explore structural studies to confirm epitope specificity if experimental data exists.