GLRX5 Antibody, HRP conjugated
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
We typically dispatch orders within 1-3 working days of receipt. Delivery times may vary depending on the shipping method and destination. Please contact your local distributor for specific delivery estimates.
Synonyms
C14orf87 antibody; Chromosome 14 open reading frame 87 antibody; FLB4739 antibody; GLRX 5 antibody; Glrx5 antibody; GLRX5_HUMAN antibody; Glutaredoxin 5 homolog antibody; Glutaredoxin related protein 5 antibody; Glutaredoxin-related protein 5 antibody; Glutaredoxin5 antibody; GRX5 antibody; MGC14129 antibody; mitochondrial antibody; Monothiol glutaredoxin-5 antibody; PRO1238 antibody
Target Names
GLRX5
Uniprot No.
Target Background
Function
GLRX5 is a monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer. It receives 2Fe/2S clusters from the scaffold protein ISCU and facilitates their transfer to apoproteins, the 4Fe/FS cluster biosynthesis machinery, or export from the mitochondrion. GLRX5 is essential for the normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1.
Gene References Into Functions
- The GLRX5 rs1007814 genotype showed a statistically marginally significant difference between cases and controls (case/control: CC 1:6; CT 112:78; TT 752:505, P=0.049361). However, no significant differences were observed in allele distribution [odds ratio (OR)=0.852805]. In men, a minor difference was found in the genotype frequency (case/control: CC 0:3; CT 72:36; TT 411:280, P=0.037370), but not in allele distribution (OR=1.142857). PMID: 27893590
- Patients with GLRX5-associated variant nonketotic hyperglycemia exhibited normal development with childhood-onset spastic paraplegia, spinal lesion, and optic atrophy. PMID: 24334290
- The crystal structure of GLRX5 revealed a tetrameric organization with the [2Fe-2S] clusters buried in the interior and shielded from the solvent by the conserved beta1-alpha2 loop. PMID: 21029046
- Glutaredoxin 5 deficiency leads to sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts. PMID: 20364084
- No GLRX5 mutations were found among sixty CSA probands examined. PMID: 19731322
- Mutations in GLRX5 are associated with sideroblastic-like microcytic anemia and iron overload. PMID: 17485548
Database Links
Involvement In Disease
Anemia, sideroblastic, 3, pyridoxine-refractory (SIDBA3); Spasticity, childhood-onset, with hyperglycinemia (SPAHGC)
Protein Families
Glutaredoxin family, Monothiol subfamily
Subcellular Location
Mitochondrion matrix.
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