SHM4 Antibody
Description
Antibodies Targeting hLSm4 (Human Like-Sm Protein 4)
hLSm4 is a component of the heptameric LSm complex involved in mRNA processing. Autoantibodies against hLSm4 have been identified in systemic lupus erythematosus (SLE) patients:
Key Findings
| Parameter | Data from SLE Studies ( ) |
|---|---|
| Prevalence in anti-Sm SLE | ~80% recognize recombinant hLSm4 |
| Exclusive LSm reactivity | 0.92% (4/434 sera) |
| Associated complexes | Co-precipitates with U4/U6 snRNP |
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Structural role: hLSm4 forms part of mRNA decapping/degradation complexes.
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Clinical relevance: Anti-hLSm4 antibodies correlate with SLE but are distinct from classical anti-Sm antibodies targeting Sm core proteins.
Synaptotagmin 4 (SYT4) Antibodies
SYT4 is a calcium sensor involved in membrane trafficking. The monoclonal antibody 5F8 targets SYT4:
Characterization of SYT4 Antibody (5F8)
| Parameter | Data ( ) |
|---|---|
| Applications | Western blot, ICC/IF, ELISA |
| Detection limit (ELISA) | 0.03 ng/ml for recombinant SYT4 |
| Reactivity | Human SYT4 (UniProt ID Q9H8B7) |
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Functional insights: SYT4 regulates neurosecretory pathways and insulin exocytosis.
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Experimental utility: Used to study SYT4 localization in neuronal and endocrine cells.
Contextual Analysis of "SHM4" Terminology
The term "SHM4" may originate from:
Research Gaps and Recommendations
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No peer-reviewed studies explicitly define "SHM4 Antibody" as a standalone entity.
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Prioritize validation of target specificity in future studies.
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Clarify whether the term refers to:
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- Structural modeling of SHM1, SHM2, and SHM4 revealed features that may explain the activity differences between the mitochondrial and cytosolic isozymes. PMID: 23800877
