GNA1 Antibody
Description
GNA1 Antibody: Function and Target
GNA1 catalyzes the acetylation of glucosamine-6-phosphate to N-acetylglucosamine-6-phosphate, a pivotal step in HBP. This pathway regulates cellular glycosylation, metabolism, and stress responses. GNA1 Antibody is used to study its expression in tissues, validate knockdown/knockout models, and explore its role in disease mechanisms.
Key Properties of GNA1
| Property | Details |
|---|---|
| Aliases | GNPNAT1, EMeg32, Phosphoglucosamine acetylase |
| UniProt ID | Human: Q96EK6; Mouse: Q9JK38 |
| Gene ID | Human: 64841; Mouse: 54342; Rat: 498486 |
| Pathway | Hexosamine biosynthesis (HBP) |
Role in Cancer Progression
GNA1 is implicated in multiple cancers, with its overexpression correlating with aggressive phenotypes and poor prognosis.
Prostate Cancer
-
Context-Dependent Role: Inhibition of GNA1 promotes proliferation in castration-resistant prostate cancer, highlighting pathway complexity .
Clinical and Therapeutic Implications
Biomarker Potential
-
BRCA: GNA1 expression correlates with tumor stage and lymph node metastasis .
-
LUAD: High expression predicts poor OS and immunotherapy resistance .
Mechanistic Insights
-
O-GlcNAcylation: GNA1 regulates UDP-N-acetylglucosamine levels, influencing protein glycosylation and signaling .
-
Metabolic Reprogramming: Links HBP activity to citrate cycle and N-glycan biosynthesis, supporting cancer metabolism .
Therapeutic Targets
-
Inhibition: May modulate glycosylation and immune evasion, though prostate cancer studies suggest context-dependent effects .
Functional Knockdown Studies
BRCA Cell Lines (MDA-MB-231 and MCF-7)
Product Specs
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- A missense mutation in the GNA1 encoding gene has been linked to growth retardation and abnormal ectopic lignin deposition under high temperature conditions. PMID: 22932674
- Quantitative PCR (qPCR) analysis has demonstrated the ubiquitous expression of AtGNA in all organs of Arabidopsis plants. PMID: 22329777
