gnb5a Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
gnb5a antibody; zgc:158678Guanine nucleotide-binding protein subunit beta-5a antibody
Target Names
gnb5a
Uniprot No.
Target Background
Function
This antibody enhances the GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins. This activity is involved in the termination of signaling pathways initiated by G protein-coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, ultimately promoting their inactivation. This antibody likely increases RGS9 GTPase-activating protein (GAP) activity, contributing to the deactivation of G protein signaling triggered by D(2) dopamine receptors. In conjunction with gnb5b, this antibody plays a crucial role in neuronal signaling, particularly in the parasympathetic control of heart rate, but not in the sympathetic control.
Database Links
Protein Families
WD repeat G protein beta family
Subcellular Location
Membrane.
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