GRIN2B Antibody

• This study revealed significant differences in GRIN2B blood levels between individuals with epilepsy and healthy controls. PMID: 30140987
• No significant association was observed between selected GRIN2B polymorphisms and personality traits. PMID: 29921740
• An absence of association was found between GRIN2B rs1805502 polymorphism and obsessive-compulsive disorder (OCD), symptom dimensions, or treatment response in South Indian patients. PMID: 29321103
• Research demonstrated that NRG1-ErbB4 signaling suppressed phosphorylation of GluN2B at position 1472 by Src kinase, with reduced levels of phosphorylation observed in human symptomatic epilepsy tissues. PMID: 28273943
• The findings indicate that alterations in the glutamate and dopamine system (GRIN2B and DRD4) in attention-deficit/hyperactivity disorder may contribute to abnormalities in local functional connectivity and its dynamic repertoire in the superior parietal area, potentially linked to dysfunction in sustained and divided attention. PMID: 28258362
• GRIN2B SNP rs219927 was associated with brain volume variations in the left posterior cingulate cortex in adolescent alcohol dependence. PMID: 27498914
• The study suggests that the GRIN2B gene might modify linguistic processes involved in information retrieval from the mental lexicon based on semantic traits, and contribute to variations in clinical symptoms related to impaired abstract thinking in patients with schizophrenia. PMID: 27240047
• This interaction between DAPK1 and NR2B mediates pathological processes like apoptosis, necrosis, and autophagy of neuronal cells observed in stroke injury. Therefore, inhibiting this interaction is a potential strategy to prevent neuronal damage. PMID: 28858643
• Five rare missense mutations in the GRIN2B gene were not associated with schizophrenia or autism spectrum disorder in a Japanese population. PMID: 27616045
• NR4A1 knockdown partly decreased surface NR2B expression by promoting NR2B internalization. PMID: 27876882
• This review highlights the association between GRIN2B and obsessive-compulsive disorder. PMID: 28608743
• GRIN2B polymorphism was linked to a twofold increase in the odds of suicide attempts in alcohol-dependent individuals. PMID: 28558131
• GRIN2B encephalopathy is often associated with movement disorders, cortical visual impairment, and malformation of cortical development, revealing novel phenotypic consequences of channelopathies. PMID: 28377535
• Mutations in the human NMDAR were investigated, and their consequences were studied using kinetic modeling and electrophysiology. PMID: 29511171
• Polymorphisms in HTR2A and GRIN2B were significantly associated with an increased risk of chronic obstructive pulmonary disease. PMID: 28900078
• In vitro DNA-binding and reporter gene assays using different allele combinations in transfected cells showed that the A allele was a gain-of-function variant associated with increased GRIN2B mRNA levels. PMID: 28439047
• Polymorphism C366G of gene GRIN2B and verbal episodic memory: No association was found with schizophrenia. PMID: 29368832
• Preliminary findings suggest that the GRIN2B gene might contribute to the susceptibility to OCD and its symptoms. PMID: 27394963
• These results demonstrate that early-onset epilepsy may be caused not only by gain-of-function variants but also by splice site mutations, particularly those affecting the splice acceptor site of the 10th intron of the GRIN2B gene. PMID: 27605359
• Results indicate that the GRIN2B single nucleotide polymorphism rs890 might be associated with schizophrenia in the Chinese Han population. PMID: 27453061
• These in vivo changes reflect alterations in glutamate transporter protein in Huntington's disease (HD), both in mice and human HD post-mortem tissue. Furthermore, N-acetylcysteine (NAC) was able to rescue changes in key glutamate receptor proteins related to excitotoxicity in HD, including NMDAR2B. PMID: 27179791
• Genetic association was observed between CYP2B6*6 and GRIN2B (rs1019385 and rs1806191) single-nucleotide polymorphisms and ketamine-induced extrapyramidal symptoms (EP) occurrence. PMID: 28252572
• This review describes mutations in GRIN2B distributed throughout the entire gene in patients with neuropsychiatric and developmental disorders. PMID: 27818011
• Genetic variants were found in GluN2B from patients with neurological or psychiatric disorders resulting in reduced surface expression of GluN2B. PMID: 28283559
• SNP rs1806201 was associated with an earlier age at onset of withdrawal symptoms in Indian alcohol-dependent subjects. PMID: 26771436
• Multiple genetic variants in GRIN2B are jointly associated with gene expression, prefrontal function, and behavior during working memory (WM). These results support the role of GRIN2B genetic variants in WM prefrontal activity in human adults. PMID: 26690829
• Findings do not support a role for GRIN2B variants in altering response to clozapine in a sample of European patients with schizophrenia deemed resistant or intolerant to treatment. PMID: 26876050
• Both Arf6 activation through GluN2B-BRAG1 during early development and the transition from BRAG1- to BRAG2-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses. PMID: 26884337
• GRIN2B (rs7301328) was significantly associated with disruptive behavior in adolescents. PMID: 26819771
• GRIN2B polymorphisms do not influence Parkinson disease age of onset in the US Caucasian population. PMID: 26627941
• GluN2B appears to exhibit allosteric regulation/inhibition by two distinct classes of antagonists. Data from in silico docking suggests that GluN2B-selective antagonists broadly divide into two distinct classes based on their binding pose. PMID: 26912815
• GRIN2B encodes the NR2 subunit of NMDA receptors, which are a class of ionotropic glutamate receptors involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission. PMID: 26321256
• Ligand binding to cell surface GD2 induces rapid and transient activation of Src-family kinases, followed by Src-dependent phosphorylation of NMDA-receptor NR2B subunits selectively. PMID: 26252487
• This study provides evidence of an association between GRIN2B polymorphisms and Schizophrenia susceptibility and symptoms in the Han Chinese population. PMID: 26020650
• Polymorphisms in DRD1, DRD2, and GRIN2B confer an increased risk of impulse control problems among Parkinson's disease (PD) patients. PMID: 25896831
• BDNF, APOE, and HSP70-1 genes, but not GRIN2B, might be associated with a risk of primary open-angle glaucoma (POAG) occurrence in the Polish population. PMID: 25893192
• This study provides further evidence supporting the contribution of GRIN2B to Developmental Dyslexia and deficits associated with this condition. PMID: 25426763
• Common variants and related haplotypes of GRIN2B are associated with autism risk. PMID: 25656819
• No significant pooled odds ratios were found for any of the six genes under different models and after stratifying for ethnicity. PMID: 25660313
• The 421C/A polymorphism was not associated with the risk of primary open-angle glaucoma occurrence. PMID: 25693086
• GluN2B-containing NMDA receptors (GluN2B/GluN1) were increased in schizophrenia in hippocampal CA3 tissue, but not in hippocampal CA1 tissue. PMID: 25585032
• Subjects with major depression exhibited significantly higher expression levels of the NMDA receptor subunit genes GRIN2B. PMID: 24925192
• The results demonstrate the contribution of Grin2b via DISC1 to the risk of Schizophrenia. PMID: 23855403
• This research provides the first evidence of GluN2 protein abnormalities in the hippocampus in schizophrenia, highlighting the hippocampal lateralization in this disorder. Only the left hippocampus exhibited a deficiency in GluN2B. PMID: 25292222
• Observations provide an initial characterization of the behavioral phenotype of GRIN2B mutation carriers. PMID: 23718928
• BDNF/TrkB signaling plays a crucial role in NRG1-stimulated NR2B regulation. PMID: 25052836
• Association of GRIN2B gene polymorphisms with paranoid schizophrenia and response to common neuroleptics in Russians and Tatars from Bashkortostan Republic. PMID: 25486778
• Genetic polymorphisms and isogenic deletions of loop-bound sequences conferred liability for cognitive performance and decreased GRIN2B expression. PMID: 25467983
• Results suggest that genetic variability in the GRIN2B gene, involved in synaptic functioning, might provide valuable insights into disease pathogenesis, continuing to attract significant attention in biomedical research due to its genetic and functional role. PMID: 24292895
• GRIN2B is likely to be related to neuro-developmental anomalies. PMID: 24503147

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HGNC: 4586

OMIM: 138252

KEGG: hsa:2904

STRING: 9606.ENSP00000279593

UniGene: Hs.504844