HDGF Antibody

1. miR139, downregulated in epithelial ovarian cancer, acts as a tumor suppressor by directly targeting HDGF. PMID: 28713954
2. Elevated serum levels of HDGF are significantly associated with bone metastasis and a poorer prognosis in non-small cell lung cancer. PMID: 28592712
3. Research suggests that HDGF knockdown inhibits cellular migration and invasion in vitro of prostate cancer by modulating the epithelial-mesenchymal transition signaling pathway, as well as the MMP2 and MMP9 signaling pathways. These findings support the notion that HDGF is a relevant protein in prostate cancer progression and may serve as a potential therapeutic target for prostate cancer and its downstream targets. PMID: 29300772
4. HDGF is overexpressed in both androgen-sensitive and androgen-insensitive prostate cell lines. Forced overexpression enhances cell viability, while knockdown reduces proliferation of benign prostate cells. Ectopic HDGF overexpression up-regulates cyclin E and BCL-2, while down-regulating BAX. Treatment with a HDGF monoclonal antibody and vitamin K2 reduces proliferation and inhibits NF-kB expression in a tumor cell line. PMID: 27692835
5. Research has explored the functional diversity of HDGF isoforms. PMID: 27926477
6. Findings indicate that the interaction of HDGF and beta-catenin may play a crucial role in the tumorigenesis of synovial sarcoma. PMID: 26842923
7. HDGF is overexpressed in hepatocellular carcinoma patients and cells. PMID: 27273265
8. miRNA497 directly targets hepatoma-derived growth factor (HDGF) in prostate cancer cells. PMID: 26780929
9. Two previously unknown HDGF isoforms, HDGF-B and HDGF-C, have been identified through alternative splicing with structurally unrelated N-terminal regions of their HATH region. PMID: 26845719
10. Studies have revealed a novel function of HDGF as a messenger of cellular condition (alarmin) that modulates cellular function, potentially serving as a biomarker for ovarian cancer. PMID: 26612514
11. HDGF and beta-catenin interact in a positive feedback loop, which plays a significant role in the carcinogenesis and progression of colorectal carcinoma. PMID: 26296979
12. HDGF is crucial in promoting malignant biological behaviors, including proliferation, migration, and invasion of hilar cholangiocarcinoma cells. PMID: 26081074
13. Hepatoma-derived growth factor overexpression is involved in liver carcinogenesis. PMID: 25938538
14. Meta-analysis results suggest that HDGF may be a new indicator of poor cancer prognosis. PMID: 25773828
15. HDGF contains conserved N-terminal HATH domains with a characteristic structural motif, namely the PWWP motif. This study defines the role of the first residue of the PWWP motif in modulating HATH domain stability and oligomer formation in binding. PMID: 26067205
16. HDGF overexpression is common in early-stage cervical adenocarcinoma. PMID: 25421244
17. The expression level of hepatoma-derived growth factor (HDGF) significantly decreased in response to the virus-associated RNAs under replication-deficient conditions. PMID: 25275311
18. HDGF can promote IHCC cell progression, including proliferation, invasion, and angiogenesis. PMID: 25262276
19. Results suggest that HDGF downregulation significantly suppresses glioma cell proliferation, migration, and invasion in vitro and tumorigenesis in vivo, likely involving the activation of both the PI3K/Akt and the TGF-beta signaling pathways. PMID: 24986090
20. These data suggest that irradiated fibroblasts promoted invasion, growth, EMT, and HDGF expression of ESCC. PMID: 25677618
21. The expression of nuclear HDGF may be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma. PMID: 25071353
22. HDGF is a potential unfavorable factor for the progression and prognosis of endometrial carcinoma. PMID: 24692842
23. Data indicate that hepatoma-derived growth factor (HDGF) was a target of miR-195 in non-small cell lung cancer (NSCLC) cells. PMID: 24891187
24. The expression of HDGF was negatively correlated with miR-141 in gastric cancer tissues; the suppressive effects of miR-141 on GC cell proliferation, colony formation, in vitro migration, and invasion were partially mediated by suppressing HDGF expression. PMID: 24276755
25. ADAM9 high expression is positively and significantly correlated with HDGF high expression in non-small cell lung cancer. PMID: 24770635
26. Patients with higher HDGF and CD31 expression levels exhibited poorer overall survival rates. PMID: 23771798
27. Positive expression of HDGF was detected in 46.2% of patients with extrahepatic cholangiocarcinoma and correlated with poor tumor differentiation. The HDGF expression group had lower survival than the negative HDGF expression group. PMID: 23793608
28. Combining p53 expression and HDGF expression significantly improved prognostic stratification for patients with Ewing family tumor. PMID: 24072730
29. These results indicate that HDGF downregulation participates in POMC-induced suppression of metastasis and EMT in melanoma. PMID: 23468531
30. Research suggests that HDGF exhibits oncogenic properties and may be a novel prognostic factor in Ewing's sarcoma. PMID: 23878072
31. Up-regulation of hepatoma-derived growth factor facilitates tumor progression in malignant melanoma. PMID: 23536873
32. The suppressive effect of miR-16 on cell proliferation, colony formation, migration, and invasion is partially mediated by inhibiting HDGF expression. PMID: 23954293
33. Studies investigating HDGF in gallbladder cancer (GBC) revealed that patients with nuclear HDGF-positive tumors had worse survival rates than those with HDGF-negative tumors. Treatment of GBC-SD and SGC-996 cell lines with HDGF-siRNA significantly reduced the proliferation of GBC cell lines. PMID: 23609195
34. Tumor samples from non-small cell lung cancers show an inverse relationship between microRNA-497 and HDGF levels, and ectopic expression of miR-497 significantly inhibited tumor growth and angiogenesis in a xenograft model. PMID: 23673296
35. Expression of a cytosolic variant of hepatoma-derived growth factor causes a redistribution of nucleolin into the cytoplasm. PMID: 23305559
36. Hepatoma-derived growth factor regulates breast cancer cell invasion by modulating epithelial-mesenchymal transition. PMID: 22247069
37. Hepatoma-derived growth factor overexpression contributes to the oncogenic processes in oral cancer cells. PMID: 22361040
38. Differential proteomic analysis of human glioblastoma and neural stem cells reveals HDGF as a novel angiogenic secreted factor. PMID: 22331796
39. High hepatoma-derived growth factor is associated with gliomas. PMID: 22037800
40. The interactome suggests that HDGF is a multifunctional protein and participates in many cellular events, including ribosome biogenesis, RNA processing, DNA damage repair, and transcriptional regulation. PMID: 21907836
41. Research found that HDGF was overexpressed in primary gastric, breast, and lung cancer tissues harboring mutant p53 genes. PMID: 22006999
42. HDGF was highly expressed in 158 non-small cell lung cancer tissues compared with normal control. PMID: 21426662
43. High HDGF is associated with hilar cholangiocarcinoma. PMID: 20848225
44. Increased nuclear expression of HDGF is a potential unfavorable prognostic factor for patients with hepatoma-derived growth factor. PMID: 21255068
45. High HDGF expression is associated with poor overall survival in patients with hepatocellular carcinoma. Down-regulation of HDGF inhibits the growth, anchorage-independent growth, migration, and invasion of HepG2 cells. PMID: 20846397
46. High hepatoma-derived growth factor is associated with colorectal carcinoma. PMID: 19924574
47. Results suggest that HDGF is involved in cell growth, cell invasion, and apoptosis. PMID: 21302807
48. This study examined the role of HDGF in keloid pathogenesis. PMID: 19432814
49. HDGF expression is elevated in postoperative stage I non-small cell lung cancer patients and is a significant independent predictive factor. PMID: 18478933
50. Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus. PMID: 11751870

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HGNC: 4856

OMIM: 600339

KEGG: hsa:3068

STRING: 9606.ENSP00000357189

UniGene: Hs.743948