HIPL1 Antibody

HIPL1 Protein Overview

• Gene Name: HHIPL1 (HHIP-like 1)

• UniProt ID: Q96JK4 (Human)

• Gene Aliases: HHIP2, KIAA1822, UNQ9245/PRO34761

• Protein Function: Belongs to the glucose/sorbosone dehydrogenase family and contains a folate-binding domain, suggesting involvement in folate metabolism or transport .

• Species Homology: High conservation across mammals (e.g., 92% homology in horses, 100% in humans, 92% in mice) .

Research Applications

HIPL1 antibodies are utilized in:

• Expression Studies: Mapping HIPL1 protein distribution in tissues or cell lines.

• Functional Assays: Investigating interactions with folate derivatives or other metabolic partners.

• Disease Research: Preliminary studies suggest potential links to cancers, though specific mechanisms remain under investigation .

Key Findings and Current Research

• Structural Insights: HIPL1’s folate-binding domain implies a role in cellular metabolism, possibly influencing pathways disrupted in cancer or developmental disorders .

• Cross-Species Utility: High homology in mammals supports translational research using animal models .

• Commercial Availability: Multiple vendors offer HIPL1 antibodies (e.g., Thermo Fisher, Sigma-Aldrich), validated for consistency in WB and IHC .

Comparative Analysis of HIPL1 Antibodies

Limitations and Future Directions

• Functional Data Gaps: The exact physiological role of HIPL1 and its relevance to diseases like cancer remain poorly characterized.

• Therapeutic Potential: No HIPL1-targeted therapies are in clinical trials as of 2025, unlike antibodies for targets such as HIV (e.g., VRC01LS) .

• Research Needs: Further studies are required to elucidate HIPL1’s interaction networks and validate its biomarker potential.