PAA1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
PAA1 antibody; GIR1 antibody; HMA6 antibody; At4g33520 antibody; F17M5.280 antibody; T16L1.10Copper-transporting ATPase PAA1 antibody; chloroplastic antibody; EC 7.2.2.8 antibody; Protein HEAVY METAL ATPASE 6 antibody; Protein glucose insensitive root 1 antibody
Target Names
PAA1
Uniprot No.
Target Background
Function
PAA1 (Plastid-Associated Protein 1) is a crucial protein that facilitates copper transfer across the plastid envelope. Its primary function is to deliver copper into the plastid stroma, a process essential for the proper functioning of copper-dependent proteins within the plastid. PAA1 exhibits selectivity for monovalent copper (Cu+), indicating its specific role in transporting this form of copper. Beyond its role in copper transport, PAA1 also plays a significant role in cell proliferation within root meristems, specifically in non-green tissues, by participating in glucose signaling pathways.
Gene References Into Functions
- The crystal structures of the nucleotide binding domain of HMA6 and HMA8 from Arabidopsis thaliana have been resolved at 1.5Å and 1.75Å resolution, respectively. These structures provide the first structural insights into the architecture of plant Cu+-ATPases. PMID: 27802305
- By integrating functional and structural data, researchers have elucidated the critical role of the cysteine and the first histidine residues within the CX3HX2H motif in the copper release process from HMA6 and HMA8. This analysis proposes a copper pathway through the membrane domain of these transporters. PMID: 27493208
- Studies have investigated the enzymatic properties of HMA6 and its affinity for copper. PMID: 26182363
- PCH1 (Plastid Chaperone 1), which is produced through alternative splicing of the PAA1 pre-mRNA, delivers Cu+ specifically to PAA1. PMID: 25468978
- Research indicates that HMA1 and PAA1 function as distinct pathways for copper import and targeting to the chloroplast. PMID: 24510941
- The plastidial Cu transporter PAA1, essential for plastid function and activity, plays a crucial role in bidirectional communication between the plastid and the nucleus in the presence of high glucose levels. PMID: 22582133
- Research has provided the first enzymatic characterization of a P(IB-1)-type plant ATPase and clearly identified PAA1 as a high-affinity Cu(I) transporter within the chloroplast envelope. PMID: 21878617
Database Links
Protein Families
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IB subfamily
Subcellular Location
Plastid, chloroplast membrane; Multi-pass membrane protein.
Tissue Specificity
Expressed in the shoots and roots.
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