HPGD Human
Description
Cancer Progression
HPGD downregulation is implicated in cervical and breast cancers:
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Cervical cancer: HPGD expression is reduced due to miR-146b-3p upregulation. Overexpression inhibits cell proliferation, migration, and anchorage-independent growth via suppressing STAT3 and AKT pathways .
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Breast cancer: Low HPGD levels correlate with tamoxifen resistance. Restoring HPGD activity enhances drug sensitivity by reducing PGE2-EP4 signaling .
| Cancer Type | HPGD Expression | Functional Impact |
|---|---|---|
| Cervical | ↓ | Promotes proliferation, metastasis |
| Breast | ↓ | Tamoxifen resistance, poor prognosis |
Pregnancy and Reproductive Health
HPGD knockout mice exhibit early pregnancy loss and premature labor due to elevated PGF2α levels, highlighting its role in maintaining gestation .
Inflammatory and Metabolic Disorders
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Hypertrophic osteoarthropathy (PHOAR1): Mutations in HPGD cause digital clubbing and skeletal abnormalities .
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Lipid metabolism: HPGD regulates fatty acid synthesis enzymes (e.g., ACLY, FAS), linking prostaglandin catabolism to lipid homeostasis .
Genetic and Clinical Implications
Disease Associations:
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Primary hypertrophic osteoarthropathy (PHOAR1): Autosomal recessive mutations in HPGD lead to skeletal deformities and digital clubbing .
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Cancer prognosis: Low HPGD expression in ERα⁺ breast cancer correlates with reduced survival .
Genetic Variants:
Product Specs
Product Science Overview
15-PGDH is a NAD±linked dehydrogenase that catalyzes the oxidation of the hydroxyl group at the 15th position of prostaglandins to a ketone, leading to a loss of their biological activity . This reaction is essential for the regulation of prostaglandin levels in various tissues, thereby modulating inflammation, pain, and other physiological processes.
