HSPA1L Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Typically, we can ship your order within 1-3 business days of receipt. Delivery times may vary depending on the method of purchase and destination. Please consult your local distributors for specific delivery times.
Synonyms
Heat shock 70 kDa protein 1 Hom antibody; Heat shock 70 kDa protein 1 like antibody; Heat shock 70 kDa protein 1-Hom antibody; Heat shock 70 kDa protein 1-like antibody; Heat shock 70 kDa protein 1L antibody; Heat shock 70kD protein like 1 antibody; HS71L_HUMAN antibody; HSP70 1L antibody; HSP70 HOM antibody; HSP70-Hom antibody; HSPA1L antibody; hum70t antibody; Spermatid specific heat shock protein 70 antibody
Target Names
Uniprot No.
Target Background
Function
HSPA1L, also known as Heat Shock Protein Family A (Hsp70) Member 1L, is a molecular chaperone involved in a wide range of cellular processes. These include protecting the proteome from stress, facilitating the folding and transport of newly synthesized polypeptides, activating the proteolysis of misfolded proteins, and regulating the formation and dissociation of protein complexes. HSPA1L plays a critical role in the protein quality control system, ensuring proper protein folding, refolding of misfolded proteins, and controlling the targeting of proteins for degradation. This is achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by the nucleotide-bound state. In the ATP-bound form, HSPA1L has a low affinity for substrate proteins. However, upon hydrolysis of ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. This process involves repeated cycles of ATP hydrolysis and nucleotide exchange, allowing for cycles of substrate binding and release. HSPA1L is also a positive regulator of PRKN translocation to damaged mitochondria.
Gene References Into Functions
- HSP70-HOM gene polymorphism is associated with susceptibility to noise-induced hearing loss. PMID: 29072670
- In a cohort of young individuals at risk for bipolar disorder, pathway analysis revealed an enrichment of the glucocorticoid receptor (GR) pathway, involving genes like MED1, HSPA1L, GTF2A1, and TAF15. This finding might explain the previously observed association between stress response and bipolar disorder risk in vulnerable populations. PMID: 28291257
- A heterozygous de novo mutation (c.830C > T; p.Ser277Leu) in HSPA1L was identified in an ulcerative colitis patient. Additionally, five other rare HSPA1L mutations (p.Gly77Ser, p.Leu172del, p.Thr267Ile, p.Ala268Thr, p.Glu558Asp) were found in six other patients. All six rare HSPA1L variant proteins exhibited decreased chaperone activity in vitro. Furthermore, three variants demonstrated dominant negative effects on HSPA1L and HSPA1A protein activity. PMID: 28126021
- Polymorphism of the HSPA1L gene is associated with the development of esophageal carcinoma. PMID: 26745065
- HSPA1L may serve as a predictive biomarker for chronic graft-versus-host disease following allogeneic stem cell transplantation. PMID: 25680846
- HSPA1L (rs2227956) is associated with a decreased risk of idiopathic pulmonary fibrosis in a Mexican population. PMID: 26496868
- Infertility in males with normal sperm parameters was not significantly associated with the HSPA1L:c.1478C>T gene polymorphism. PMID: 26160076
- HSP70-hom polymorphisms modify the association of diethylhexyl phthalates exposure with insulin resistance. PMID: 25044062
- In HSPA1L T2437C polymorphisms, there were no significant differences in the frequencies of the variant homozygous genotype in patients compared to controls. PMID: 23666708
- Findings suggest that polymorphisms of HSP70 genes are associated with the development of gastric cancer and duodenal ulcers in a population at high risk for gastric cancer in Costa Rica. PMID: 24051039
- A study investigated the relationship between blood levels of HSP70 and HSP90 and genotypes of HSP70, GSTT1, and GSTM1 polymorphic variants in individuals chronically exposed to mercury. PMID: 23330093
- HSP70-hom gene polymorphism may play a role in graft-versus-host disease after hematopoietic stem cell transplantation. PMID: 17060867
- Researchers examined the relationship between the HSP70-hom polymorphism and the clinical characteristics of the malignancy at the time of diagnosis. PMID: 17578680
- A strong association was observed between HSP-70/Hom rs2075800 G and uveitis in patients with sarcoidosis. PMID: 17591867
- Polymorphisms in HSP70-HOM genes are associated with noise-induced hearing loss. PMID: 18813331
Database Links
Protein Families
Heat shock protein 70 family
Tissue Specificity
Expressed in spermatids.
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