HSPBP1 Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze/thaw cycles.
Lead Time
Typically, we can ship products within 1-3 business days of receiving your order. Delivery time may vary depending on the purchasing method or location. Please contact your local distributor for specific delivery time details.
Synonyms
1500019G21Rik antibody; FES1 antibody; Heat shock protein 70 binding protein antibody; Heat shock protein 70 interacting protein antibody; Heat shock protein binding protein 1 antibody; Heat shock protein-binding protein 1 antibody; Heat-shock 70-KD protein-binding protein 1 antibody; HPBP1_HUMAN antibody; Hsp 70 binding protein antibody; Hsp 70 interacting protein antibody; Hsp70 binding protein 1 antibody; Hsp70 binding protein 2 antibody; Hsp70 interacting protein 1 antibody; Hsp70 interacting protein 2 antibody; Hsp70-binding protein 1 antibody; Hsp70-binding protein 2 antibody; Hsp70-interacting protein 1 antibody; Hsp70-interacting protein 2 antibody; HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 antibody; HSPA-binding protein 1 antibody; HSPBP antibody; HspBP1 antibody; HspBP2 antibody; PP1845 antibody
Target Names
Uniprot No.
Target Background
Function
This antibody inhibits HSPA1A chaperone activity by altering the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. It also interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
Gene References Into Functions
- Research suggests a critical role of HspBP1 in the differential activities of CHIP/Hsp70 in neuronal and glial cells, contributing to the greater vulnerability of neurons to misfolded proteins in neurodegenerative diseases. PMID: 28847953
- Downregulation of Hsp70 and HspBP1 is a distinctive characteristic in patients with preterm prelabor rupture of membranes. PMID: 28497897
- Our findings clearly demonstrate that HspBP1 acts as an endogenous negative regulator of HIV-1 gene expression and replication by suppressing NF-kappaB-mediated activation of viral transcription. PMID: 26538602
- Oxidative stress, leading to the formation of disulfide bonds, can affect the stability and conformational mobility of human HspB1. PMID: 24898092
- BAG-1M and HspBP1 have distinct impacts on the dynamic composition of steroid receptor folding complexes. PMID: 24454860
- It has been shown that HspBP1 binds Tag7 in the conditioned medium of tumor CSML0 cells, thereby preventing the formation of the cytotoxic Tag7-Hsp70 complex. PMID: 22037021
- High gene expression of HspBP1 is associated with leukemia. PMID: 20694586
- Research reports cooperative interactions involving Hsp70, Hsp40, and TPR1 that enhance Hsp70-dependent folding of chemically denatured substrates. PMID: 14503850
- Detection of hsp70 may be used as a screening marker for the diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer, potentially supplementing the diagnostic value of conventional cytology. PMID: 14761400
- BAG2 binds to the carboxyl terminus of Hsp70-interacting protein (CHIP) and provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by CHIP. PMID: 16169850
- The results demonstrate that Hsp70 and HspBP1 are not coordinately regulated but provide evidence that an increase in the ratio of HspBP1 to Hsp70 correlates with apoptosis, similar to reducing the amount of Hsp70. PMID: 16677834
- Stress-induced heat shock protein 70 (Hsp70) effectively protects cells against ultraviolet ray-induced apoptosis in melanocytes by penetrating mitochondrial and lysosomal membranes. PMID: 16950797
- Upon the formation of huntingtin aggregates, endogenous cytosolic huntingtin, Hsc70/Hsp70 (heat shock protein and cognate protein of 70kDa), and syntaxin 1A become aggregate-centered. PMID: 17208201
- HspBP1, by antagonizing the prosurvival activity of Hsp70, sensitizes tumor cells to cathepsin-mediated cell death. PMID: 17855353
- Association between endogenous LAP2alpha and Hsp70 in non-transfected cells was confirmed by co-immunoprecipitation. PMID: 18261988
- The two chaperones, HSP72 and HSPBP1, interact both physically and functionally, leading to the activation of the EGFR-ERK1/2 signaling pathway. PMID: 18986301
- Results indicate that low HspBP1 expression could be a marker of tumor aggressiveness. PMID: 18987994
- Our data suggest that HIP may prevent inclusion formation by facilitating the constitutive HSC70 refolding cycle and possibly by preventing aggregation. PMID: 19183265
- HspBP1 may play a role in tumor (dys)regulation of chaperone proteins. PMID: 19659607
- The cochaperone HspBP1 binds to and inhibits Hsp70 activity. PMID: 9830037
Database Links
Tissue Specificity
Ubiquitous.
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