Hoxd13a is a sequence-specific transcription factor that plays a critical role in a developmental regulatory system. This system provides cells with specific positional identities along the anterior-posterior axis.
Gene References Into Functions
Research findings support the theory that modifications in 5'Hoxd gene expression, through the acquisition of novel enhancer elements, facilitated the evolution of fins and the subsequent emergence of tetrapod limbs. PMID: 23237954
Data reveals that cis-regulatory elements regulating Hoxd gene expression in distal limbs are present in fish. PMID: 21765002