HYAL3 Antibody
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Product Specs
Buffer
Phosphate-buffered saline (PBS) with 0.02% sodium azide, 50% glycerol, pH 7.3. Store at -20°C. Avoid repeated freeze-thaw cycles.
Lead Time
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Synonyms
Hyal-3 antibody; HYAL3 antibody; HYAL3_HUMAN antibody; Hyaluronidase 3 antibody; Hyaluronidase-3 antibody; Hyaluronoglucosaminidase 3 antibody; Hyaluronoglucosaminidase-3 antibody; LUCA-3 antibody; LUCA14 antibody; LUCA3 antibody; Lung carcinoma protein 3 antibody; Minna14 antibody
Target Names
HYAL3
Uniprot No.
Target Background
Function
HYAL3 antibody facilitates sperm penetration through the cumulus cell layer surrounding the egg by degrading hyaluronic acid. It plays a role in inducing the acrosome reaction in sperm. HYAL3 is also involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected for ovulation. It induces ovarian granulosa cell apoptosis, potentially through an apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Notably, HYAL3 exhibits no hyaluronidase activity in embryonic fibroblasts or granulosa cells in vitro.
Gene References Into Functions
- The relative expression of hyalurosome (CD44, HAS3, HB-EGF) genes was found to be reduced in patients prior to topical treatment and significantly increased following treatment. PMID: 25138066
- Mutations in the HYAL3 gene are rare in Chinese lung squamous cell carcinoma patients and may contribute to lymph node metastasis. PMID: 23549009
- Polymorphisms in HYAL3 are potentially involved in glaucomatous neurodegeneration. PMID: 22960332
- Nodular basal cell carcinoma is associated with elevated hyaluronic acid levels, accompanied by upregulation of gene expression for HAS3, HYAL3, and RHAMM, compared to normal adjacent skin. PMID: 20849445
- Overexpression of HYAL3 is associated with colorectal cancer. PMID: 20849597
- Hyal3-deficient sperm demonstrated delayed cumulus penetration and reduced acrosomal exocytosis. PMID: 20586096
- Characterization of the murine hyaluronidase gene region reveals complex organization and co-transcription of Hyal1 with downstream genes, Fus2 and Hyal3. PMID: 11929860
- Alternative mRNA splicing regulates cellular expression of enzymatically active hyaluronidase. PMID: 12084718
- Downregulation of HYAL3 is associated with small cell lung cancer and glioma. PMID: 12684632
Database Links
Protein Families
Glycosyl hydrolase 56 family
Subcellular Location
Secreted. Cell membrane. Cytoplasmic vesicle, secretory vesicle, acrosome. Endoplasmic reticulum. Early endosome.
Tissue Specificity
Expressed in sperm. Highly expressed in epidermis of the skin, where it is expressed intracellularily in the deep horny layer (at protein level). Bone marrow, testis and kidney.
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