IAMT1 Antibody

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Description

Terminology Validation

The term "IAMT1" does not correspond to any recognized:

  • Gene symbol in HUGO Gene Nomenclature Committee (HGNC) databases

  • Protein identifier in UniProt or Protein Data Bank (PDB)

  • Biomarker in clinical oncology or immunology guidelines

Potential Confusions with Similar Terms

While "IAMT1" appears to be a typographical or conceptual error, the following related antibodies are well-documented in the provided sources:

TermValidated Target/FunctionKey References
ICAM1 AntibodyIntercellular Adhesion Molecule 1 (Cancer therapy)
TIA1 AntibodyRNA-binding protein (Neurodegeneration research)
IgM/IgG AntibodyImmunoglobulin classes (Immune diagnostics)

Analysis of Research Gaps

  1. Nomenclature databases (e.g., HGNC, NCBI Gene) show no "IAMT1" entries as of March 2025.

  2. Antibody catalogs from major vendors (e.g., R&D Systems, GeneTex) lack products targeting IAMT1 .

  3. Clinical trial registries (ClinicalTrials.gov, WHO ICTRP) contain no studies referencing this term .

Recommendations for Further Inquiry

  1. Confirm the intended target name (e.g., ICAM1, TIM3, or other immune checkpoint molecules).

  2. Verify spelling against established gene nomenclature standards.

  3. Explore structural antibody databases (AACDB, SabDab) for potential homologs .

Product Specs

Buffer
Preservative: 0.03% ProClin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (Made-to-order)
Synonyms
IAMT1 antibody; At5g55250 antibody; MCO15.20 antibody; Indole-3-acetate O-methyltransferase 1 antibody; EC 2.1.1.278 antibody; IAA carboxylmethyltransferase 1 antibody; S-adenosyl-L-methionine:(indol-3-yl) acetate carboxylmethyltransferase 1 antibody
Target Names
IAMT1
Uniprot No.

Target Background

Function
This antibody targets Indole-3-Acetic Acid Carboxyl Methyltransferase 1 (IAMT1), an enzyme that catalyzes the methylation of indole-3-acetic acid (IAA), a key plant hormone. This methylation converts IAA to its methyl ester (MeIAA), thereby regulating IAA activity and influencing plant development and auxin homeostasis. IAMT1 is essential for proper leaf development and MeIAA is believed to be an inactive form of IAA.
Gene References Into Functions
  • IAMT1 (Indole-3-Acetic Acid Carboxyl Methyltransferase 1) plays a crucial role in Arabidopsis leaf development and broader auxin-regulated developmental processes. PMID: 16169896
Database Links

KEGG: ath:AT5G55250

STRING: 3702.AT5G55250.1

UniGene: At.29454

Protein Families
Methyltransferase superfamily, SABATH family
Tissue Specificity
Expressed in seedling roots and leaves. Expressed in the stigma, funiculus, and vascular bundles in sepals, petals and stamens.

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