Ica1 Antibody
Description
Overview of ICA1 and ICA1 Antibody
ICA1 is a 69 kDa protein encoded by the ICA1 gene, localized in the cytosol and membrane-bound forms on the Golgi complex and secretory vesicles . It functions in membrane trafficking and synaptic plasticity . As an autoantigen, ICA1 is associated with:
The ICA1 antibody detects this protein in research and diagnostic assays, aiding studies on autoimmune mechanisms and neurodegenerative pathways.
Key Applications of ICA1 Antibodies
ICA1 antibodies are widely used in:
Notable Commercial Antibodies:
| Supplier | Clonality | Host | Reactivity | Applications |
|---|---|---|---|---|
| Novus Biologicals | Polyclonal | Rabbit | Human | WB, IHC, IHC-Paraffin |
| R&D Systems | Polyclonal | Goat | Human, Mouse | WB, IHC, Flow Cytometry |
| Bio-Techne | Monoclonal | Mouse | Human | IP |
Role in Autoimmunity
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Type 1 Diabetes: ICA1 autoantibodies correlate with T1D progression, driven by IgG1/IgG3 isotypes .
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Genetic Regulation: Polymorphisms in the ICA1 promoter increase binding of the autoimmune regulator (AIRE), reducing ICA1 expression in thymic cells and breaking immune tolerance .
Neurodegenerative Disease Link
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Alzheimer’s Disease (AD): ICA1 levels are reduced in AD patients and mouse models. It modulates amyloid precursor protein (APP) processing via the PICK1-PKCα pathway, influencing β-amyloid production .
Technical Considerations
Product Specs
Components: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
ICA69 (Immunoglobulin-like cell adhesion molecule 1) may play a role in neurotransmitter secretion.
The following studies highlight the diverse roles of ICA69:
- ICA69 deficiency exacerbates formalin-induced persistent pain hypersensitivity. (PMID: 25547463)
- Reduced thymic ICA69 expression is directly linked to autoimmunity affecting multiple ICA69-expressing organs, suggesting a novel mechanism in multi-organ autoimmune disease development. (PMID: 25088457)
- The ICA69 C-terminal domain interacts with PICK1, influencing the trafficking of the PICK1-PKCα complex and cerebellar plasticity. (PMID: 24358315)
- PICK1 and ICA69 are crucial regulators of insulin granule formation and maturation. (PMID: 23630453)
- Polymorphisms in the NOD Ica1 core promoter may influence AIRE-mediated ICA69 downregulation in medullary thymic epithelial cells. (PMID: 22447927)
- ICA69 knockout nonobese diabetic mice develop diabetes but exhibit resistance to disease acceleration by cyclophosphamide. (PMID: 11751995)
