IDD4 Antibody

IDD4 in Plant Immunology

IDD4 (INDETERMINATE-DOMAIN 4) is a transcription factor in plants that regulates immune responses and growth. It functions as a repressor of basal immunity and PAMP-triggered immunity, as demonstrated in studies using Pseudomonas syringae infection models .

Key Findings:

• Mechanism of Action:

  • IDD4 binds to the ID1 motif in gene promoters and regulates defense-related genes (e.g., WRKY38, PR5) and developmental pathways .

  • Phosphorylation by MAP kinase MPK6 enhances its DNA-binding activity, linking immune signaling to transcriptional regulation .

Idd4 in Mouse Genetics (Type 1 Diabetes)

The Idd4 locus on chromosome 11 in mice is associated with susceptibility to type 1 diabetes (T1D). It maps to a 1.4 Mb region containing genes involved in antigen presentation and inflammation .

Key Findings:

• Candidate Genes:

  • Alox15 (arachidonate 15-lipoxygenase): Linked to lipid metabolism and immune regulation .

  • Cxcl16 (chemokine ligand): Plays roles in lymphocyte trafficking and inflammation .

  • Psmb6 (proteasome subunit): Involved in protein degradation and antigen processing .

Potential Confusion with IgG4 Antibodies

The query may involve a misinterpretation of "IDD4" as "IgG4," a well-studied antibody subclass. IgG4 antibodies are unique due to their Fab-arm exchange and anti-inflammatory properties, playing roles in allergy, autoimmunity, and tumor immunology .

Key Features of IgG4 Antibodies:

• Structural Uniqueness:

  • Undergo Fab-arm exchange, forming bispecific antibodies that block antigen binding .

  • Low affinity for Fcγ receptors and C1q, limiting immune activation .