IFNGR2 Antibody

1. A study identified an SNP, rs9978223, on the IFNGR2 gene associated with an increased risk of acute myocardial infarction in patients from India. PMID: 29434065
2. A crystal structure of the extracellular portion of human interferon-gamma receptor 2 (IFNGR2) was determined at 1.8 Å resolution using molecular replacement. PMID: 27599734
3. The IFNGR2Q64R polymorphism is correlated with male sex and paranoid schizophrenia in Tunisians. PMID: 27563937
4. The IFN-gammaR2 T168N mutant exhibits restricted diffusion within distinct actin nanodomains, hindering the conformational changes required for JAK/STAT activation by IFN-gamma. Removing IFN-gammaR2 T168N-bound galectins restored lateral diffusion in lipid nanodomains and JAK/STAT signaling in patient cells, whereas adding galectins impaired these processes in control cells. PMID: 27499022
5. Two unrelated pediatric patients with underlying IFNGR2 deficiency were diagnosed with fatal hemophagocytic lymphohistiocytosis. PMID: 25592983
6. The expression of IFNGR2 was significantly higher in patients with rheumatoid arthritis (RA) compared to control subjects, with a strong correlation to the severity of radiographic damage. PMID: 25708927
7. This is the first study demonstrating an association between SNPs and liver fibrosis in the general population. PMID: 25301852
8. We report a molecular study of the two known patients with autosomal recessive, partial interferon-gamma receptor (IFN-gammaR)2 deficiency. PMID: 23963039
9. IFN-gammaR2-deficient monocytes induce a higher percentage of IL-17(+) cells from both healthy and IFN-gammaR2-deficient CD4(+) T cells. PMID: 23459074
10. IFNGR2 haploinsufficiency might contribute to clinical tuberculosis in children residing in areas of endemic disease. PMID: 23161749
11. JAK2 is a crucial factor stabilizing IFN-gammaR2 surface expression in Th17 cells from patients with acute mountain sickness, rendering them sensitive to IFN-gamma. PMID: 22219326
12. Polymorphisms in IFNGR2 might confer resistance to tuberculosis development in newly infected individuals. PMID: 22057826
13. Perturbation of IFN-gammaR2 internalization by mutating the LI(255-256) motif triggers timely coordinated activation of IFN-gamma/STAT1 signaling pathways, leading to T cell apoptosis. PMID: 20709103
14. HBV viraemia appears to have substantial heritability, and polymorphisms in the IFNGR2 gene seem to be associated with variations in viraemia. PMID: 20980339
15. Among the two IFNg receptors, IFNGR2 expression appears to be the determining factor controlling the physiological response of target cells to IFNgamma. PMID: 20587546
16. Microglial and oligodendrocytic expression levels of IFN-gamma-R2 are considerably lower than the astrocytic expression levels in the human CNS. PMID: 20554027
17. Abnormalities in the intracellular processing and protein expression of the IFN-gamma R2 in response to specific stimuli, such as IFN-gamma and M. leprae membrane proteins, have been observed in adherent cells of leprosy patients. PMID: 20039824
18. The discovery of the anti-Bax activity of the cytoplasmic domain of IFNgammaR2 provides insights into the mechanism of cell death regulation by IFNgamma and Bax. PMID: 19657228
19. Phages displaying fusion proteins with full-length PNRC2 (proline-rich nuclear receptor co-regulatory protein 2), known to be a cofactor for other nuclear receptors, and with a polypeptide of the bHLH corepressor TLE1 bound to AF-1. PMID: 14651967
20. In pre-eclampsia, IFN-gamma R2 protein expression mirrors that observed in early placental development. PMID: 15585559
21. A higher frequency of +874T interferon gamma, both in heterozygosity and homozygosity, particularly when simultaneous, plays a role in predisposing to gluten intolerance and increasing the risk of celiac disease. PMID: 15979955
22. Two IFN-gammaR2 chains interact through species-specific determinants within their extracellular domains. Notably, these determinants also participate in the interaction of IFN-gammaR2 with IFN-gammaR1. PMID: 16467876
23. interferon-gamma (IFN-gamma) receptor PMID: 16467883
24. Single Nucleotide Polymorphisms in IFNGR2 are associated with gastric cancer. PMID: 16885196
25. The interaction between Sirt2 and 14-3-3 beta/gamma constitutes a novel mechanism for the negative regulation of p53, in addition to the well-established Mdm2-mediated repression. PMID: 18249187
26. No significant alterations were observed in the expression of IFN-gamma receptor beta-chain on the surface of alveolar macrophages obtained from smokers. PMID: 19269302

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HGNC: 5440

OMIM: 147569

KEGG: hsa:3460

STRING: 9606.ENSP00000290219

UniGene: Hs.634632