IGF2BP3 Antibody
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Description
Research Applications and Findings
IGF2BP3 antibodies are critical for investigating the protein’s role in cancer biology. Below are key research insights:
Table 1: IGF2BP3 in Cancer Biology
Mechanistic Insights
IGF2BP3 antibodies have elucidated the protein’s molecular functions:
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RNA Stabilization: IGF2BP3 binds to the 3′-UTRs of oncogenic mRNAs (e.g., EGFR, MYC) and protects them from miRNA-mediated degradation, often via m6A modification .
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Immune Modulation: In gliomas and prostate cancer, IGF2BP3 expression correlates with increased infiltration of CD8+ T cells and macrophages, suggesting a dual role in tumor progression and immune response .
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Drug Resistance: IGF2BP3 overexpression in colorectal cancer reduces sensitivity to cetuximab by stabilizing EGFR mRNA, highlighting its potential as a therapeutic target .
Clinical and Therapeutic Implications
Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze / thaw cycles.
Lead Time
Typically, we can ship your order within 1-3 business days of receiving it. Delivery time may vary depending on the purchasing method or location. Please consult your local distributors for specific delivery details.
Synonyms
Cancer/testis antigen 98 antibody; CT98 antibody; DKFZp686F1078 antibody; hKOC antibody; IF2B3_HUMAN antibody; IGF II mRNA binding protein 3 antibody; IGF-II mRNA-binding protein 3 antibody; IGF2 mRNA binding protein 3 antibody; IGF2 mRNA-binding protein 3 antibody; IGF2BP3 antibody; IMP 3 antibody; IMP-3 antibody; Insulin like growth factor 2 mRNA binding protein 3 antibody; Insulin-like growth factor 2 mRNA-binding protein 3 antibody; KH domain containing protein overexpressed in cancer antibody; KH domain-containing protein overexpressed in cancer antibody; KOC 1 antibody; KOC1 antibody; VICKZ 3 antibody; VICKZ family member 3 antibody; VICKZ3 antibody
Target Names
Uniprot No.
Target Background
Function
IGF2BP3 is an RNA-binding factor that facilitates the recruitment of target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This process, known as 'caging,' enables mRNA transport and transient storage. IGF2BP3 also modulates the rate and location at which target transcripts interact with the translational machinery, shielding them from endonuclease attacks or microRNA-mediated degradation. It binds to the 3'-UTR of CD44 mRNA, stabilizing it and promoting cell adhesion and invadopodia formation in cancer cells. IGF2BP3 also interacts with beta-actin/ACTB and MYC transcripts, and binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.
Gene References Into Functions
- Research suggests that the insulin-like growth factor-II mRNA-binding protein 2 and 3 (IMP2/3)-miR-200a-progesterone receptor axis forms a double-negative feedback loop and represents a potential therapeutic target for Triple-negative breast cancer (TNBC). PMID: 29217458
- THADA fusion is a mechanism associated with IGF2BP3 activation and IGF1R signaling in thyroid cancer. PMID: 28193878
- High IMP3 expression in adult mature testicular teratomas supports their malignant nature. PMID: 24605891
- Tubal secretory cells exhibiting IMP3 signatures, demonstrating growth advantage, could potentially serve as a latent precancer biomarker for tubal or pelvic serous carcinomas in women. PMID: 25014991
- Studies indicate that pancreatic carcinogenesis involves elevated IMP3 mRNA expression, making it a potential diagnostic and prognostic marker, as well as a therapeutic target for pancreatic cancer. PMID: 25183049
- The combination of p16/IMP3 expression has been found to improve discrepancies between cervical cytologic and histologic diagnoses. PMID: 23923073
- Elevated IMP3 expression is associated with hepatocellular carcinoma. PMID: 24647926
- Research strengthens the association of IMP3 with the regulation of epithelial to mesenchymal transition in breast cancers. PMID: 25031719
- Post-transcriptional regulation of cyclins D1, D3 and G1, and proliferation of human cancer cells depend on IMP-3 nuclear localization. PMID: 23812426
- IMP3 upregulates HMGA2 mRNA by opposing its interaction with Ago2/let-7. PMID: 24703842
- Findings indicate that IMP3 is overexpressed in sacral chordoma, and this expression is associated with tumor invasion and recurrence. PMID: 24135846
- IMP3 may play a role in the progression of high-grade serous carcinoma of the fallopian tube. PMID: 25038792
- Absence of IMP3 expression is associated with a significantly reduced risk of lymphovascular invasion in pT1 esophageal adenocarcinoma. PMID: 24726263
- Diffuse IMP3 expression (>25%) in MAC from patients with gastric adenocarcinoma was associated with shorter survival. PMID: 24457229
- This review focuses on studies examining IMP3 expression in different cancers and emphasizes the potential utility of IMP3 in routine surgical pathology practice. PMID: 24713990
- IMP3 expression was positive in esophageal adenocarcinoma and Barrett's esophagus with high-grade dysplasia. Barrett's esophagus and esophageal squamous epithelium showed no IMP3 expression. PMID: 25141312
- High IMP3 was associated with metastasis in prostate cancer. PMID: 24615121
- High-grade dysplasia and gastric carcinomas can be differentiated from low-grade dysplasia and inflammatory lesions of the gastric mucosa with high specificity and good sensitivity using a combination of the immunohistochemical markers IMP3 and p53. PMID: 24966917
- IMP-3 expression is not a useful discriminator between dysplastic nevi and melanoma, nor a good prognostic marker in melanoma. PMID: 26403409
- The specificity for IMP3, GLUT-1, and EMA for differentiating malignant mesotheliomas and benign mesothelial proliferations was 100%. PMID: 25376377
- Expression in preoperative biopsy material is predictive of perineural invasion in patients with oral squamous cell carcinoma. PMID: 27863864
- IMP3 appears to play a significant role in tumor invasion in patients with lung adenocarcinoma and may serve as a useful prognostic biomarker in these patients. PMID: 26608347
- IMP3 represents a biomarker of unfavorable prognosis for clear cell carcinomas of the ovary, even in stage I patients. PMID: 26837693
- Results suggest that IMP3 facilitates pancreatic ductal adenocarcinoma progression by enhancing the pro-metastatic behavior of tumor cells. PMID: 25886367
- EGF stimulates IMP-3 expression. PMID: 26386725
- MP3 may play a role in hydatidiform moles progression and could serve as a prognostic biomarker for this disease. PMID: 27238915
- Testing for a combination of elevated IMP3 and Lin28B levels could further facilitate the identification of a patient subgroup with the worst ovarian cancer prognosis. PMID: 26158423
- Research demonstrates that SOX2 is a transcriptional target of SLUG. These data establish a novel mechanism of breast tumor initiation involving IMP3 and provide a rationale for its association with aggressive disease and poor outcome. PMID: 25982283
- This is the first study evaluating IMP3 immunohistochemical expression in Phyllodes tumor. Its expression correlates with histological grade and could be used in the differential diagnosis of fibroepithelial tumors and in prognostication. PMID: 26353850
- IMP3 is a reliable marker for the diagnosis of colorectal cancer in endoscopic biopsies. PMID: 28412210
- Positive expression of IMP3 in spinal giant cell tumor was associated with increased microvessel density and expression of IGF2. PMID: 25740666
- Tissue overexpression of IMP3 might be used as a predictor of advanced disease or lymph node metastasis, and is associated with poorer prognosis in gastric cancers. PMID: 28011483
- IMP-3 plays a role in promoting migration and invasion of melanoma cells by modulating the expression of HMGA2 and predicts poor prognosis in melanoma. PMID: 25380351
- The role of IMP3 as a marker of poor outcome in gliomas. PMID: 25695077
- IMP3 directly interacts with ULBP2 mRNA, leading to ULBP2 transcript destabilization and reduced ULBP2 surface expression, and indirectly downregulates MICB with a mechanism functionally distinct from that of ULBP2. PMID: 26982091
- This study demonstrated that genes overexpressed in Pilomyxoid Astrocytoma vs. Pilocytic Astrocytoma, ranked according to fold-change, included developmental genes H19, DACT2, COL2A1; COL1A1 and IMP3. PMID: 25521223
- Describes chromosome 12p abnormalities and IMP3 expression in prepubertal pure testicular teratomas. PMID: 26826410
- This study aimed to demonstrate the usefulness of mRNA expression levels of IMP3 in brush cytology specimens combined with cytology for the diagnosis of malignant biliary stricture. PMID: 27399126
- IMP-3 and its protein partners ILF3/NF90 and PTBP1 bind to the 3'UTRs of the cyclin mRNAs and protect them from the translational repression induced by miRNA-dependent recruitment of AGO2/GW182 complex in human cancer cells. PMID: 27840950
- IMP3 promotes renal cell carcinoma cell migration and invasion by activation of the NF-κB pathway. PMID: 25919292
- Overexpression of IMP3 and EGFR were significantly associated with shorter periods of metastasis-free and disease-free survival of malignant phyllodes tumor of the breast. PMID: 27137988
- S100P achieved 96.4% sensitivity, 93.3% specificity, 98.2% PPV, 87.5% NPV, and 95.8% total accuracy, while IMP3 achieved 91.2% sensitivity, 86.7% specificity, 96.2% PPV, 72.2% NPV, and 90.3% total accuracy for pancreatic ductal adenocarcinoma (PDA). Both markers were sensitive and specific for the diagnosis of PDA. PMID: 27839709
- CK5/6, IMP3, and TTF1 immunostaining appears to be useful for improving the accuracy of cytological diagnoses between reactive mesothelial cells, metastatic adenocarcinoma of lung and non-lung origin in pleural effusion. PMID: 25337222
- Our study clearly demonstrated differentiation-dependent expression of IMP3 in chondrosarcoma and suggests IMP3 as a novel marker for differentiating problematic cases of enchondroma from well-differentiated chondrosarcomas. PMID: 26948096
- It was concluded that IMP3 and nucleophosmin cannot be a routine diagnostic marker for discrimination of papillary carcinomas and benign lesions. IMP3 positive staining was scarce in IMP3 positive papillary carcinomas, although the specificity of IMP3 is 100%. PMID: 25389240
- MP3 expression in biopsy specimens could be used to predict lymph node metastasis and TNM stage in colorectal cancer patients. PMID: 26617820
- IGF2BP3 influences a malignancy-associated RNA regulon by modulating miRNA-mRNA interactions. PMID: 27210763
- IGF2BP3 acts as a human ontogenic master switch that restricts megakaryocyte development by modulating a lineage-specific P-TEFb activation mechanism. PMID: 28481226
- Results suggest that IGF2BP3 promotes eIF4E-mediated translational activation through the reduction of EIF4E-BP2 via mRNA degradation, leading to enhanced cell proliferation. PMID: 26522719
- Research comprehensively revealed the oncogenic role of IGF2BP3 in gastric tumorigenesis and confirmed its activation is partly due to the silencing of miR-34a. These findings identified a useful prognostic biomarker and provided clinical translational potential. PMID: 28399871
Database Links
Protein Families
RRM IMP/VICKZ family
Subcellular Location
Nucleus. Cytoplasm. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules.
Tissue Specificity
Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic
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