IGMT3 Antibody

Potential Misinterpretations of "IGMT3"

• IgM vs. IgG3: The term may conflate IgM (Immunoglobulin M) and IgG3 (Immunoglobulin G subclass 3), two distinct antibody classes with well-characterized roles:

  • IgM: A pentameric antibody critical for early immune responses; promotes pathogen agglutination and complement activation .

  • IgG3: A proinflammatory IgG subclass with a long hinge region, strong Fcγ receptor binding, and potent complement activation .

• TIM-3: T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), an immunoregulatory receptor studied in cancer immunotherapy . While not an antibody itself, it is a therapeutic target for monoclonal antibodies (e.g., anti-TIM-3 mAbs like RMT3-23) .

IgM Antibodies

IgG3 Antibodies

Research Tools and Annotation Methods

• IgMAT: A bioinformatics tool for annotating antibody sequences across species, not an antibody itself .

• Antibody Engineering: Technologies like single-cell sequencing enable the discovery of antibodies targeting glycan epitopes or conserved viral regions .

Recommendations for Clarification

• If referring to TIM-3-targeted antibodies, see preclinical studies on anti-TIM-3 mAbs (e.g., RMT3-23) that restore antitumor immunity .

• If inquiring about IgG3-specific functions, refer to its role in autoimmune diseases, infections, and therapeutic design .