IL12A Antibody

• These results suggest that IL-12A rs568408 may contribute to the etiology and severity of asthma, making it a potentially valuable predictive and diagnostic biomarker for the disease. PMID: 28600552
• This study provides evidence that the AA genotype of IL-12A rs568408 is associated with an increased lung cancer risk among Taiwanese, particularly those with smoking habits. PMID: 30396953
• IL-35 may play a role in renal involvement in patients with lupus nephritis. PMID: 29576585
• The IL-35 levels in CagA(+) H. pylori-infected participants from peptic ulcer and H. pylori-infected asymptomatic groups were lower than individuals infected with CagA(-) strains. PMID: 29938865
• This research demonstrates the expression of IL35 in oral lichen planus lesions. PMID: 29633015
• IL-12 receptor signaling in keratinocytes initiates a protective transcriptional program that limits skin inflammation. PMID: 27892456
• This study investigated the relationship of IL35 in patients with immunorelated hemocytopenia (IRH). Serum levels of IL35 were decreased in untreated patients with IRH compared to remission patients (P<0.01) and were significantly associated with clinical indexes. PMID: 29257310
• IL-35 may be involved in the pathogenesis of Primary biliary cirrhosis. PMID: 29445068
• The overall results showed that cancer risk was increased by IL-12A rs568408 (GG versus GA + AA: P = 0.004; G versus A: P = 0.005) and IL-12B rs3212227 (AA versus AC + CC: P = 0.004; CC versus AA + AC: P = 0.03; A versus C: P = 0.007) polymorphisms. However, no significant associations were detected between the IL-12A rs2243115 polymorphism and cancer risk in either the overall or the subgroup analyses. PMID: 28408727
• IL-35 is a relatively newly discovered member of the IL-12 family, characterized by its unique structure as a dimer formed by two subunits. Recent findings have shown abnormal expression of IL-35 in inflammatory autoimmune diseases, and functional analysis suggests that IL-35 is crucial in the onset and development of these diseases. [Review] PMID: 29729445
• The results suggest that IL12A genotype predicts a higher risk of death and progression in NSCLC patients. PMID: 28807247
• IL-35 expression was significantly increased in patients with chronic hepatitis C and was positively correlated with the levels of viral RNA. PMID: 28644966
• Pancreatic ductal carcinoma cells produce IL35 to recruit monocytes via CCL5 and induce macrophage to promote angiogenesis via expression of CXCL1 and CXCL8. PMID: 28989066
• Polymorphisms of IFNL3 rs8099917 and IL12A rs568408 contribute to survival of HD patients, but not as independent factors. PMID: 28525983
• The anti-EGFR viroplexes with IL-12 and salmosin genes exhibited the most effective therapeutic efficacy in a mouse tumor model, especially when combined with doxorubicin. PMID: 27191929
• Baseline serum IL-12 levels were significantly higher in those pediatric hematopoietic stem cell transplantation recipients who did not develop acute graft versus host disease. PMID: 27751764
• Our data indicate that decreased expression of IL-35 in tumor tissues might contribute to the progression of hepatocellular carcinoma. PMID: 27329841
• Circulating mir-21 and expression of the IL-12p35 gene were observed significantly downregulated in current smokers with CAD. PMID: 27765464
• Simultaneous elevated circulating levels of IL-18 and IL-12 increased the event rate after 2 years in Coronary Artery Disease patients, independent of hyperglycemia. PMID: 27058587
• The study revealed that post-therapeutic recovery of circulating IL-35 concentration might be an independent predictor for effective response to IST in pediatric AA. PMID: 28211781
• Epstein Barr Virus miRNAs collectively and specifically suppress the release of proinflammatory cytokines such as IL-12, repressing the differentiation of naive CD4(+) T cells to Th1 cells. PMID: 27621419
• Assembly-induced folding is key in IL-12 family biogenesis and secretion. The identification of essential disulfide bonds underlying this process lays the basis for a simplified yet functional IL-12 cytokine. PMID: 28325840
• The plasma levels of interleukin-35 were significantly higher in the hepatocellular carcinoma patients than the controls. PMID: 27699510
• Importantly, treatment of NK cells from HIV-infected patients with IL-12 reversed the multiple defects in binding, granule polarization, perforin content, and perforin release, restoring anticryptococcal activity. PMID: 27555306
• The results of this case-control study suggest that IL-12A, IL-12B, IL12RB1, IL12RB2, and IL23R do not contribute genetically to the susceptibility of Takayasu arteritis in Chinese populations. PMID: 26987707
• This study introduces IL-35 as a new treatment option for pemphigus. PMID: 27855302
• Suberoylanilide hydroxamic acid significantly inhibited IL-12p40 and IL-23p19 mRNA synthesis without affecting IL-12p35 mRNA transcription. PMID: 27240992
• This study shows that IL-12A gene polymorphism contributes to the risk of hepatocellular carcinoma in conjunction with chronic hepatitis C virus infection in Egyptian patients. PMID: 27819525
• The results suggest that hepatocellular carcinoma (HCC) cell apoptosis was suppressed at least partially through HBx-induced miR-21 by targeting IL-12. PMID: 27571873
• These data indicate that increased serum IL-35 could act as a disease activity marker and as a risk factor for esophageal involvement in idiopathic inflammatory myopathies. PMID: 27502600
• The results of Expression Quantitative Trait Loci analysis showed that the risk alleles of rs4679868 and rs6441286 were significantly associated with decreased expression of IL12A in lymphoblastoid cell lines derived from individuals of Chinese Han ancestry. These findings demonstrate that IL12A is associated with Primary Biliary Cirrhosis in the Chinese Han population. PMID: 27175695
• The highest gene transfer ability was achieved by the DTPA-conjugated PEI at the conjugation degree of 0.1%, where the level of IL-12 production increased up to twofold compared to that of the unmodified PEI. PMID: 26801817
• TLR3 is required to induce full IL-12p70 secretion. PMID: 26956584
• Interleukin-12 A rs17810546 was positively associated with celiac disease. PMID: 27043536
• Data show that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) levels were significantly elevated in patients with influenza infection. PMID: 26844658
• The functional single nucleotide polymorphism IL-12A rs2243115 GG genotype may increase the risk of rheumatoid arthritis in rheumatoid factor negative patients. PMID: 26375522
• Low IL12 expression levels are associated with Acute Leukemia. PMID: 26514528
• This study indicated that the rs568408 variation in the IL-12A gene could influence disease susceptibility and was associated with the severity of oral lichen planus in an East Chinese cohort. PMID: 25258182
• These results demonstrate for the first time a role of Cdk5/p35 in the regulation of cell cycle progression modulated by TGF-beta1. PMID: 26966064
• IL-35 was elevated in the bone marrow of adult AML patients, and this increase was correlated with the clinical stages of malignancy, suggesting that IL-35 is involved in the pathogenesis of AML. PMID: 26431888
• The p41 fragment has also been shown to reduce the secretion of interleukin-12 (IL-12/p70) during the subsequent maturation of treated dendritic cells. PMID: 26960148
• IL-35 plays a protective role in the pathogenesis of rheumatoid arthritis. PMID: 26370008
• Findings demonstrate that IL-12 is significantly increased in chronic hepatitis B patients and that viral protein HBx induces IL-12 expression in hepatocytes through the activation of the PI3K/Akt pathway. PMID: 26062743
• Serum levels of IL-35 increased during normal pregnancy and decreased in recurrent spontaneous abortion. PMID: 26042836
• IL-35 is involved in the pathogenesis of Guillain-Barre Syndrome through its influence on the function of CD4+ T cells. PMID: 26225474
• Elevated circulating IL-35, particularly in the early phase, its decrease after treatment initiation, and a positive association between synovial fluid IL-35 and disease activity support an involvement of IL-35 in the pathogenesis of RA. PMID: 26204444
• Gene-gene interaction analysis showed that subjects carrying the IL-12A rs568408AG/AA and IL-12B rs3212227AA genotypes had a 2.40-fold increased risk of CRC (OR = 2.40; 95 % CI, 1.14-5.07). PMID: 26104769
• The distribution of interleukin (IL)-12 (IL12; 1188A/C), IL17 (A7488G), and IL-23 receptor (IL23R; +2199A/C) gene polymorphisms in patients with alopecia areata was investigated. PMID: 26017027
• Genome-wide association study in an admixed case series reveals IL12A as a new candidate in Behcet disease. PMID: 25799145
• These results might indicate an important new role for IL-35 as an autocrine growth factor in pancreatic cancer growth. PMID: 25073578

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