IL17E Antibody
Product Specs
Product Science Overview
Interleukin 17E (IL-17E), also known as IL-25, is a member of the IL-17 cytokine family, which includes six structurally related cytokines: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, and IL-17F . IL-17E is unique within this family due to its distinct biological functions and low sequence homology with IL-17A (only 16%) .
IL-17E is primarily produced by T helper 2 (Th2) cells and plays a crucial role in promoting Th2-type immune responses . This cytokine is involved in the induction of pro-inflammatory cytokines such as IL-4, IL-5, IL-13, and eotaxin, which are essential for the development of allergic diseases . Additionally, IL-17E has been shown to induce the activation of NF-kappaB and stimulate the production of IL-8 .
IL-17E is a pro-inflammatory cytokine that contributes to the body’s defense against extracellular bacterial infections . It achieves this by recruiting immune cells, such as monocytes and neutrophils, to the site of infection . Moreover, IL-17E plays a significant role in the pathogenesis of various autoimmune and inflammatory disorders, including psoriasis .
Mouse Anti-Human IL-17E Antibody is a monoclonal antibody specifically designed to target and bind to human IL-17E. This antibody is commonly used in research to study the expression and function of IL-17E in various biological processes . It is also utilized in techniques such as Western blotting, ELISA, and flow cytometry to detect and quantify IL-17E levels in different samples .
The antibody is produced by immunizing mice with recombinant human IL-17E protein, followed by the isolation and purification of the specific antibody-producing cells . These cells are then fused with myeloma cells to create hybridomas, which are capable of producing large quantities of the monoclonal antibody .
Mouse Anti-Human IL-17E Antibody has several applications in scientific research:
- Detection and Quantification: It is used to detect and quantify IL-17E levels in various biological samples, including serum, plasma, and tissue lysates .
- Functional Studies: Researchers use this antibody to study the biological functions of IL-17E, including its role in immune responses and disease pathogenesis .
- Therapeutic Development: The antibody is also employed in the development of therapeutic strategies targeting IL-17E for the treatment of autoimmune and inflammatory diseases .
