IL2RB Antibody

1. Research has shown that the assembly of the interleukin receptor beta/gamma-associated protein complex is characterized in IL-2- and IL-15-activated T-cells. PMID: 27463037
2. A haplotype encompassing two single nucleotide polymorphisms (SNPs) in the IL-2RB gene was found to be associated with an increased risk of erosion in ACPA positive Rheumatoid arthritis patients. PMID: 26203933
3. Downregulation of CD112 resulted in a reduced ability of DNAM-1 to bind to the surface of both virus-infected and gD-transfected cells. PMID: 25352670
4. Expression of the IL-2 receptor beta chain is significantly diminished on T cells in ANCA-associated vasculitis. PMID: 24648606
5. In patients with anti-citrullinated protein antibody positive rheumatoid arthritis, the AC haplotype of IL-2RB was associated with a higher rate of erosions at baseline and at 1-year follow-up compared to other haplotypes. PMID: 24200909
6. This study provides the first evidence demonstrating the functionality of heterodimeric combinations of IL-2R and IL-6R subunits for signaling. PMID: 23926072
7. The MiniSTR marker D22S1045 (locus 22q12.3) is located near the breakpoint region of the Ewing Sarcoma gene. However, it was found to be neutral in relation to EWS in a case-control study analyzing allele frequencies and linkage disequilibrium. PMID: 24112992
8. Findings suggest that oxalate-induced activation of the renal IL-2Rbeta pathway may lead to a range of cellular changes, the most common of which is the induction of inflammation. PMID: 24523387
9. Data indicate that both CgammaCR-CD127(+) (composed of Interleukin-7 (IL-7) tethered to IL-7Ralpha/CD127) and CgammaCR-CD122(+) CD8(+) T((E/CM)) engraft in mice and persist in the absence of exogenous cytokine administration. PMID: 23628622
10. Evidence suggests that cross-talk occurs between cAMP/PKA and the IL-2R beta/Jak3/Stat5b cascade in T-cells. PMID: 23341462
11. A single nucleotide polymorphism (SNP) in IL2RB has been associated with lung cancer. PMID: 22573796
12. Research found significant differences between the D22S1045 locus in the Maghreb population and other populations. PMID: 21674833
13. Genetic variants of IL2RB may be associated with the development of acute rejection episodes and may help predict risk in kidney transplantation patients. PMID: 21839273
14. The LTR of the THE1D retroelement family has been domesticated as an alternative promoter of human IL2RB, the gene encoding the beta subunit of the IL-2 receptor. PMID: 21865161
15. Lyn coimmunoprecipitates with the interleukin-2 beta receptor and JAK3 proteins in human T-cell leukemia virus type 1-infected T-cells. PMID: 21345943
16. IL-15R alpha, which exhibits the majority of binding affinity for IL-15, functions as a potent IL-15 agonist by enhancing its binding and biological effects through the IL-15R beta/gamma heterodimer. PMID: 16284400
17. Data suggest that co-expression of ZNF300 and Egr1 leads to enhanced IL-2Rbeta promoter activity, indicating that ZNF300 is another regulator of the human IL-2Rbeta promoter. PMID: 20585888
18. IL-2Rbeta undergoes ectodomain shedding, generating an intracellular fragment that is biologically functional due to its phosphorylation, association with STAT5A, and ability to increase cell proliferation. PMID: 20495002
19. Investigations have revealed alternate signaling pathways from the interleukin-2 receptor. PMID: 11750878
20. In four cell lines of human adult T cell lymphoma/leukemia origin, the three IL-2R subunits are compartmentalized together with HLA glycoproteins and CD48 molecules in the plasma membrane. PMID: 11856346
21. SHB links the IL2 receptor for signal transduction and mediates apoptosis. PMID: 12200137
22. Peptide p1-30, composed of the 30 amino-terminal residues of human interleukin-2, binds as a tetramer to the dimeric IL-2Rbeta2 receptor. PMID: 12676936
23. The development of breast tumors is associated with increased expression of IL-2 receptor beta, and this expression also seems to be linked to the malignancy of the tumor. PMID: 14680494
24. Cultures in the presence of peptide epitopes to this receptor inhibited T cell proliferation. PMID: 15350462
25. The interleukin-2 receptor beta-627*C homozygote and C allele are correlated with higher susceptibility to endometriosis. PMID: 16084898
26. The location of the G245R polymorphism next to the proximal cytokine receptor homology segment suggests a genetic association with the development of visceral leishmaniasis. PMID: 17108990
27. Studies have shown that precise sorting of IL-2Rbeta from early to late endosomes is mediated by Hrs, a known sorting component of the ubiquitin-dependent machinery, in a manner independent of UIM-ubiquitin binding. PMID: 18445679
28. Research found that PI3K & STAT5 signaling pathways are necessary for granulysin expression and IL-2Rbeta induction, and IL-2Rbeta induction is a prerequisite for granulysin expression. Both signaling pathways are defective in CD4+ T cells from HIV-infected patients. PMID: 18490721
29. This report describes the selective expansion of genetically modified T cells using an antibody/IL2RB receptor chimera. PMID: 18589435
30. High serum IL-2R levels are associated with peripheral T-cell lymphoma, unspecified. PMID: 18592269
31. The uncleaved 12-kDa form of p12(I) resides in the ER and interacts with the beta and gamma(c) chains of the interleukin-2 receptor (IL-2R), the heavy chain of the major histocompatibility complex (MHC) class I, as well as calreticulin and calnexin. PMID: 18791162
32. The preformed complexes between gamma c and IL-2Rbeta or IL-9Ralpha promote signaling by the JAK3 A572V mutant without ligand, identified in several human cancers. PMID: 18829468
33. The C627T polymorphism in the IL2RB gene is not associated with the risk of endometriosis in Korean women. PMID: 19602517

HGNC: 6009

OMIM: 146710

KEGG: hsa:3560

STRING: 9606.ENSP00000216223

UniGene: Hs.474787