IL31 Antibody

1. Eosinophils, a type of white blood cell, are a primary source of IL-31 in bullous pemphigoid, a skin disease. This cytokine may contribute to the itchiness experienced by patients. PMID: 29693698
2. Lung cancer patients carrying specific genetic variations in IL-31 (homozygous CC for rs7977932 or the G allele of rs4758680) exhibited significantly worse prognoses compared to those without these variations. The rs7977932 CC genotype was strongly linked to metastasis and poor survival in lung adenocarcinoma. PMID: 29791232
3. Research suggests that these genetic variations in IL-31 (rs7977932 and rs4758680) might be associated with the development and progression of epithelial ovarian cancer in the Chinese population. PMID: 29484036
4. Studies show that decreased serum levels of IL-31 correlate with treatment response in patients with Relapsing-Remitting Multiple Sclerosis. PMID: 29050818
5. A comprehensive review delves into the role of IL-31 in chronic skin diseases and explores its potential diagnostic and therapeutic applications in managing these conditions. PMID: 29046191
6. Research findings, along with existing literature, indicate that lower IL-31 concentrations in patients' serum may be associated with its role in the JAK/STAT signaling pathway, a key player in the development of autoimmune blistering diseases. PMID: 28808661
7. Genetic variations in the IL-31 gene were strongly associated with the susceptibility to dilated cardiomyopathy and contributed to poorer outcomes in patients with this heart condition. PMID: 28572699
8. Research suggests that CXCL13, another molecule, rather than IL-31, may hold greater clinical value for diagnosing and predicting outcomes in hepatocellular carcinoma, a type of liver cancer. PMID: 27663978
9. Initial research into the role of the IL-31/IL-31R axis in cancer came from studies on patients with mycosis fungoides/Sezary syndrome, the most common type of cutaneous T cell lymphoma. Tumor cells were found to produce IL-31, and its levels in the blood correlated with the intensity of itching. PMID: 28408397
10. IL31 and its receptor, IL31RA, are highly expressed in various human and mouse cancer cell lines, as well as in tumor samples from cancer patients. Murine colon carcinoma cells lacking IL31 exhibited increased invasive and migratory properties in laboratory settings. PMID: 28147314
11. Studies show that IL-31 might be involved in the development of asthma and rhinitis. Allergies to dust mites and mugwort can significantly increase IL-31 levels. PMID: 28303765
12. While serum levels of TSLP, a cytokine involved in allergic responses, were unaffected by co-occurring allergies and atopic conditions, serum levels of IL-31, IL-33, and sST2, other molecules involved in inflammation, were slightly affected. There was a positive association between TSLP, IL-31, and IL-33, and an inverse relationship between IL-33 and sST2. PMID: 27152943
13. Research suggests that the IL-31 gene might play a role in the development of systemic lupus erythematosus, an autoimmune disease. PMID: 26769434
14. High expression of IL31 is associated with Endometrial Cancer. PMID: 27340318
15. In a chronic myeloid leukemia patient experiencing itching while receiving imatinib mesylate treatment, IL-31 and IL-33 serum levels were significantly higher than in controls. Imatinib can potentially cause keratinocyte injury, leading to the release of IL-33. This, in turn, interacts with its receptor on mast cells, triggering the secretion of IL-31. The IL-31/IL-33 axis might be involved in the development of skin side effects associated with imatinib mesylate treatment. PMID: 26316486
16. Specific genetic variations in the IL-31 gene might contribute to the development of mastocytosis, a condition characterized by an overgrowth of mast cells, and IL-31 might play a role in inducing itching in patients with this condition. PMID: 27276346
17. Serum and pleural fluid IL-31 levels are elevated in tuberculous pleural effusion, a type of fluid accumulation in the chest cavity. PMID: 26864868
18. Both SCF (stem cell factor) and IL-31 play significant roles in mediating inflammation and increasing the severity of atopic asthma, a type of asthma. PMID: 26853551
19. IL-31 influences keratinocyte differentiation in various ways, and the IL-1 cytokine network is a major downstream effector of IL-31 signaling in disrupting the skin barrier. PMID: 26944931
20. This article provides an overview of oncostatin M and interleukin-31, focusing on their cytokine properties, receptors, signal transduction, and physiological functions. PMID: 26198770
21. Based on analysis of serum levels and receptor expression, the research does not suggest a primary role for IL-31 in the development of Mycosis fungoides/Sezary syndrome. PMID: 25488078
22. Research findings link TGF-beta1 and IL-31 to the progression from chronic hepatitis B to liver cirrhosis. Their levels strongly correlate with disease severity. PMID: 25710085
23. Increased IL-31 serum levels have been observed in postmenopausal women with decreased bone mineral density. PMID: 26449657
24. Research suggests a potential systemic involvement of IL-31 and the absence of a systemic involvement of IL-33 in allergic contact dermatitis. PMID: 26357000
25. This study highlights the crucial requirements for IL-31 signaling and its counter-regulation by SOCS3, a protein involved in regulating immune responses. PMID: 26306032
26. IL-31 expression in allergic rhinitis exacerbates and amplifies Th2 inflammation, a type of immune response, as well as mucin production in the nose. PMID: 25285475
27. IL-31 serum levels were significantly higher in patients with cutaneous T-cell lymphoma compared to the control group. However, no positive correlation was found between IL-31 serum levels and itching. PMID: 25176053
28. IL-31 is overexpressed in the affected skin of lichen planus, a skin disease, but its expression does not correlate with the intensity of itching. PMID: 25756056
29. IL-31 levels were elevated after IVIG treatment (intravenous immunoglobulin) in patients with Kawasaki disease, and this increase was significantly associated with the formation of coronary artery lesions. PMID: 25122210
30. A case report details a case of sporadic lichen amyloidosis, a skin disease, with high IL31 expression. PMID: 24573820
31. Research suggests that the severity of atopic dermatitis in a Polish population is associated with specific genetic variations in the IL-31 gene, raising further questions about the role of IL-31 in itching in atopic dermatitis. PMID: 25534405
32. Increased levels of Th2 cytokines, a type of immune response, correlated with IL-31 expression in nasal polyps, suggesting a possible regulatory role for IL-31 in the development of nasal polyps. PMID: 24515918
33. Research suggests that IL-31 might be a gene associated with the development of rheumatoid arthritis, an autoimmune disease. PMID: 25572240
34. The IL-31/IL-31receptor axis contributes to tumor growth in human follicular lymphoma. PMID: 25283844
35. TARC (thymus and activation-regulated chemokine) and interleukin-31 might be biomarkers for adult atopic dermatitis. PMID: 24984931
36. IL-31 might play a significant role in the pathophysiology of uremic pruritus, itching associated with kidney failure. PMID: 25270263
37. IL-31-positive cells were observed as mononuclear infiltrating cells and as CD11b co-expressing cells in severe atopic dermatitis samples. PMID: 24667097
38. Research shows that STAT6 and NF-kappaB, proteins involved in cellular signaling, are central to mediating IL-31 expression induced by IL-4/IL-33. PMID: 24943220
39. EGFR-TK inhibitors, a type of cancer treatment, can potentially cause keratinocyte injury, leading to the release of IL-33. This, in turn, interacts with its receptor on mast cells, inducing the secretion of various factors, including IL-31, which can cause skin manifestations. PMID: 23794184
40. IL-31 appears to be another factor that stimulates sweating. PMID: 23874436
41. CD4+CD26- malignant cells specifically produce IL-31, and clinical improvement in itching correlates with reduced IL-31 levels in the blood. PMID: 23698099
42. IL-31 and IL-31RA are upregulated in patients with allergic rhinitis and induce MUC5AC gene expression in human airway epithelial cells. PMID: 23392388
43. IL-31 triggers pro-inflammatory effects in activated human macrophages through STAT-1 and 5 phosphorylation. IL-31-induced ERK 1/2 activation contributes to the underlying mechanism of Th1 cytokine IL-12 suppression in macrophages. PMID: 23621408
44. IL-31 is not a typical Th2 cytokine but is likely expressed by various cells in allergic situations where IL-4 is present, potentially contributing to the allergic reaction. PMID: 23694808
45. Research hypothesizes that altered regulation of IL-31 gene expression influences the clinical course of atopic dermatitis. Existing research and findings support a significant role for IL-31 gene polymorphism in the development of atopic dermatitis. PMID: 22827739
46. The IL-31-631 T>G polymorphism was significantly associated with IL-31 blood levels but not with disease susceptibility. PMID: 21952721
47. T cells in chronic atopic dermatitis (AD) skin produce IL-31, and AD lesions contain increased levels of these IL-31-producing T cells. PMID: 22621183
48. IL-31 serum levels correlate with the SCORAD score (a measure of atopic dermatitis severity), sleeplessness, and Th2 cytokines, including IL-4 and IL-13, in sixty children with the extrinsic type of atopic dermatitis. PMID: 22509760
49. IL-31-specific activation of dendritic cells might be part of a positive feedback loop that drives the progression of inflammatory skin diseases. PMID: 22539792
50. Distinct SPINK5 and IL-31 gene variants (SNPs) were associated with the development of atopic eczema and non-atopic hand dermatitis in Taiwanese nurses. PMID: 22017185

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HGNC: 19372

OMIM: 609509

KEGG: hsa:386653

STRING: 9606.ENSP00000366234

UniGene: Hs.569071