INPP5B Antibody, Biotin conjugated
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Typically, we can ship products within 1-3 business days of receiving your order. Delivery times may vary depending on the method of purchase and location. Please consult your local distributor for specific delivery timelines.
Synonyms
4 antibody; 5-trisphosphate 5-phosphatase antibody; 5PTase antibody; 75 kDa inositol polyphosphate 5 phosphatase antibody; 75 kDa inositol polyphosphate-5-phosphatase antibody; 75kDa antibody; EC 3.1.3.36 antibody; I5P2_HUMAN antibody; Inositol polyphosphate 5-phosphatase II antibody; Inositol polyphosphate-5-phosphatase B antibody; Inositol polyphosphate-5-phosphatase; 75kDa antibody; INPP5B antibody; Inpp5b protein antibody; INPP5P antibody; MGC65156 antibody; MGC71303 antibody; OTTHUMP00000004726 antibody; OTTHUMP00000004727 antibody; OTTHUMP00000004728 antibody; Phosphoinositide 5 phosphatase antibody; Phosphoinositide 5-phosphatase antibody; Type II inositol 1,4,5 trisphosphate 5 phosphatase antibody; Type II inositol-1 antibody
Target Names
Uniprot No.
Target Background
Function
INPP5B is a phosphatase enzyme that plays a crucial role in cellular signaling by hydrolyzing phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3). This activity modulates cellular signaling events.
Gene References Into Functions
- Fibroblasts from patients with Dent-2 disease, characterized by OCRL mutations, exhibit phenotypic variability independent of INPP5B compared to Lowe syndrome cells. PMID: 25305077
- Structural analysis of human INPP5B in complex with phosphoinositide substrate analogs revealed a membrane interaction patch, suggesting its involvement in sequestering substrates from the lipid bilayer. PMID: 24704254
- A study comparing mouse Inpp5b and human INPP5B revealed differences in their transcription, splicing, and amino acid sequence. These observations provide a foundation for investigating the functional basis behind their distinct roles in compensating for Ocrl function loss. PMID: 20872266
- The homologous phosphatase Inpp5b failed to complement the Ocrl1-dependent cell migration defect. PMID: 19700499
- INPP5B is localized to the early secretory pathway, including the Golgi apparatus and ER-to-Golgi intermediate compartment (ERGIC). PMID: 17956944
- The N-terminal region of OCRL, but not INPP5B, binds clathrin heavy chain. PMID: 19536138
Database Links
Protein Families
Inositol 1,4,5-trisphosphate 5-phosphatase type II family
Subcellular Location
Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane. Golgi apparatus.
Tissue Specificity
Platelets.
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