INPP5F Antibody, FITC conjugated
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
We typically dispatch orders within 1-3 business days of receipt. Delivery times may vary depending on the purchasing method and location. Please consult your local distributor for specific delivery timelines.
Synonyms
INPP5F antibody; KIAA0966 antibody; SAC2 antibody; MSTP007 antibody; MSTP047 antibody; Phosphatidylinositide phosphatase SAC2 antibody; EC 3.1.3.25 antibody; Inositol polyphosphate 5-phosphatase F antibody; Sac domain-containing inositol phosphatase 2 antibody; Sac domain-containing phosphoinositide 4-phosphatase 2 antibody; hSAC2 antibody
Target Names
Uniprot No.
Target Background
Function
INPP5F is an inositol 4-phosphatase that primarily acts on phosphatidylinositol 4-phosphate. It may be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, enabling sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 positions of inositol. This process plays a critical role in endocytic recycling. INPP5F acts as a regulator of TF:TFRC and integrins recycling pathways, and is also involved in cellular migration mechanisms. It modulates the AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. Additionally, it negatively regulates the STAT3 signaling pathway by inhibiting STAT3 phosphorylation and nuclear translocation. INPP5F is a functionally important modulator of cardiac myocyte size and the cardiac response to stress. It may also play a role as a negative regulator of axon regeneration following central nervous system injuries.
Gene References Into Functions
- Research has identified inositol polyphosphate-5-phosphatase F (INPP5F) as a prognostic factor for progression-free survival in Chronic lymphocytic leukemia. PMID: 26430724
- Studies suggest that INPP5F acts as a potential tumor suppressor in gliomas through inhibition of the STAT3 pathway. Dysregulation of INPP5F may contribute to gliomagenesis. PMID: 25476455
- Sac2 colocalizes with early endosomal markers and is recruited to transferrin-containing vesicles during endocytic recycling. PMID: 25869669
- Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. PMID: 19875726
Database Links
Subcellular Location
Membrane, clathrin-coated pit. Early endosome. Recycling endosome.
Tissue Specificity
Ubiquitous. Highly expressed in brain.
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