ITGA8 Antibody, FITC conjugated
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Typically, we can ship your order within 1-3 business days of receiving it. Delivery times may vary depending on the shipping method and destination. Please consult your local distributors for specific delivery time information.
Synonyms
Integrin alpha 8 antibody; Integrin alpha-8 heavy chain antibody; Integrin alpha-8 light chain antibody; ITA8_HUMAN antibody; ITGA 8 antibody; ITGA8 antibody
Target Names
Uniprot No.
Target Background
Function
Integrin alpha-8/beta-1 plays a crucial role in the development of the kidney and potentially other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the R-G-D sequence found in various ligands, including TNC, FN1, SPP1, TGFB1, TGFB3, and VTN. NPNT is likely its functional ligand in kidney development. As a neuronal receptor for TNC, it mediates cell-cell interactions and regulates neurite outgrowth in sensory and motor neurons.
Gene References Into Functions
- ITGA2B and ITGA8 are associated with prognosis in patients with clear cell renal cell carcinoma. PMID: 26198048
- Recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which contribute to the interaction between the ureteric bud and the metanephric mesenchyme, have been identified in 15 out of 590 families. PMID: 24700879
- Mutations in ITGA8 have been identified as a genetic cause of bilateral renal agenesis, indicating that, at least in some cases, bilateral renal agenesis is an autosomal-recessive disorder. PMID: 24439109
- The ITGA8 gene may play gender-specific roles in the development of schizophrenia. PMID: 23153507
- Data analysis suggests that Itga8 expression is independent of CArG box-serum response factor but dependent on myocardin, potentially through an as yet unidentified sequence module located distal to the promoter region. PMID: 23142384
- Integrinalpha8 mRNA levels were significantly lower in LSCC tissues compared to corresponding adjacent normal tissues. PMID: 20942236
- Alpha8beta1 integrin is essential for proper anoikis (programmed cell death) in normal human intestinal epithelial crypt cells, while its loss contributes to anoikis resistance. PMID: 20678483
- ITGA8 is expressed during kidney development. PMID: 12060755
- ITGA8 plays a regulatory role in mesangial cell phenotype, potentially promoting adhesion but inhibiting migration and proliferation of mesangial cells. Alpha8 integrin could play a significant role in maintaining tissue integrity in the glomerulus during glomerular injury. PMID: 12787402
- Genomic analysis of the human integrin subunit alpha8 gene has been conducted. PMID: 15579315
- Mammary carcinoma cells express alpha8 integrin. PMID: 15592496
- A polymorphism in the ITGA8 promoter influences the progression of renal failure in ADPKD (autosomal dominant polycystic kidney disease). PMID: 18277079
- High-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction involving the RGD motif and LFEIFEIER sequence. PMID: 19342381
- In intestinal crypt cells, integrin alpha8beta1 is closely involved in the regulation of adhesion, migration, and cell proliferation via a predominant RhoA/ROCK-dependent mechanism. PMID: 19527220
Database Links
Involvement In Disease
Renal hypodysplasia/aplasia 1 (RHDA1)
Protein Families
Integrin alpha chain family
Subcellular Location
Membrane; Single-pass type I membrane protein. Cell membrane.
Tissue Specificity
Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
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