ITGAD Antibody
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In Stock 
Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Stored at -20°C. Avoid freeze/thaw cycles.
Lead Time
Typically, we can ship products within 1-3 business days after receiving your order. Delivery time may vary depending on the purchasing method or location. Please consult your local distributors for specific delivery details.
Synonyms
ITGAD antibody; Integrin alpha-D antibody; ADB2 antibody; CD11 antigen-like family member D antibody; Leukointegrin alpha D antibody; CD antigen CD11d antibody
Target Names
Uniprot No.
Target Background
Function
Integrin alpha-D/beta-2 (ITGAD) acts as a receptor for ICAM3 and VCAM1. It is believed to play a crucial role in the atherosclerotic process, potentially contributing to the clearance of lipoproteins from plaques and the phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the bloodstream.
Gene References Into Functions
- Research indicates that increased expression of CD11d/CD18 on proinflammatory macrophages may represent a common mechanism for macrophage retention at inflammatory sites, thereby promoting chronic inflammation and disease development. PMID: 28500072
- These findings expand the potential for CD11d to regulate lymphocyte migration and tissue retention, shedding light on a possible role for CD11d in leukocyte biology and disease. PMID: 27881604
- alpha(D)beta(2) is a significant component of the integrin repertoire in both circulating and tissue myeloid leukocytes in humans. PMID: 25415295
- Anti-CD11d treatment has shown improvements in functional recovery in a rat model of repeated concussion. PMID: 23414334
- The communication between neutrophils and NK cells is mediated by ICAM-3 and CD11d/CD18, respectively. PMID: 21712539
- Increased CD11d expression has been observed in the subcutaneous white adipose tissue of obese adult women, suggesting a potential link between CD11d and obesity. PMID: 21508205
- A longer isoform of gut-enriched Kruppel-like factor 4 (GKLF), termed GKLFa, interacts with the CD11d promoter. PMID: 15561714
- Multiple CD11d domains contribute to its intracellular localization and association with CD18. PMID: 19571252
Database Links
Protein Families
Integrin alpha chain family
Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.
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