ITGAE Antibody

1. Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors. PMID: 30006565
2. Pxn binding to the CD103 cytoplasmic tail triggers alphaEbeta7 integrin outside-in signaling, promoting CD8(+) T-cell migratory behavior and effector functions. PMID: 29021139
3. The CD103+CD4+/CD4+ ratio is not a reliable discriminator between sarcoidosis and other causes of lymphocytic alveolitis, even when combined with the CD4+/CD8+ ratio, and lacks significant diagnostic value for sarcoidosis. PMID: 27230039
4. CD103 expression in human dendritic cells is differentially regulated by retinoic acid and Toll-like receptor ligands. PMID: 28087652
5. CD103 tumor cells were detected in 41% (16/39) of lymph node-involved adult T-cell leukemia/lymphoma. PMID: 26813744
6. Levels of GZMA and ITGAE mRNAs in colon tissues can identify patients with ulcerative colitis who are most likely to benefit from etrolizumab. Importantly, these expression levels decrease with etrolizumab administration in biomarker(high) patients. PMID: 26522261
7. PD-1(+)CD103(+) CD8 TIL might regain functional antitumor activity, an effect that could potentially be augmented by immune modulation. PMID: 25957117
8. This report highlights the diagnostic challenges and the need for consensus in categorizing clonal CD103(+) lymphocytosis in patients with refractory celiac disease. PMID: 25637255
9. Cell-sorting experiments have demonstrated that IDO1 expression is found in a subset of CD1a(+)CD14(-)langerin(+) cells, expressing CD103. PMID: 25584868
10. CD103 expression occurs most frequently in gastrointestinal T-cell lymphomas. PMID: 25025448
11. Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer. PMID: 24190978
12. Using a human CTL system model based on a CD8(+)/CD103(-) T cell clone specific for a lung tumor-associated antigen, we demonstrated that the transcription factors Smad2/3 and NFAT-1 are two critical regulators of this process. PMID: 24477908
13. Memory CD103+ CD8 T cells that persist within the brain after an acute infection with vesicular stomatitis virus are bona fide tissue resident memory cells. PMID: 22922816
14. Lymphoid tissue (LT)-resident CD8alpha-positive dendritic cells (DCs) and non(LT)-derived CD103-positive DCs express transgenic XCR1 and are characterized by a unique transcriptional fingerprint, irrespective of their tissue of origin. PMID: 21948982
15. These findings support the usefulness of CD123 and CD103 to aid in the differential diagnosis of B-cell lymphoproliferative disorders. PMID: 21917686
16. Studies indicate that the mechanisms regulating the retention of tissue-resident memory T cells include TGF-beta-mediated induction of CD103 and downregulation of CCR7. PMID: 21739671
17. Results show that binding of the human alphaE I domain to oral and skin keratinocytes is independent of E-cadherin. PMID: 20875079
18. ITGAE plays a role in mucosal immunity and graft rejection. PMID: 12370249
19. Involvement of the adhesive ligand pair CD103-E-cadherin in human thymocyte cell proliferation. PMID: 12414996
20. Differential up-regulation of CD103 expression on lamina propria lymphocytes in Crohn's disease may indicate differential humoral or cellular regulation in inducing CD103 molecules on lymphocytes in patients with this disease. PMID: 14532999
21. CD103 promotes destruction of renal allografts by CD8 T cells. PMID: 15196058
22. Integrin/activation marker CD103 (alphaEbeta7) is expressed on Epstein-Barr virus-specific tonsil-resident (but not peripheral blood mononuclear leukocyte-derived) cytotoxic T lymphocytes. PMID: 16177076
23. CD103 expression on dendritic cells influences the balance between effector and regulatory T cell activity in the intestine. PMID: 16216886
24. Human alloantigen-induced CD103+ CD8+ T cells possess functional features of regulatory T cells. PMID: 16920912
25. CD8+/CD103+ tumor-reactive T lymphocytes infiltrating epithelial tumors likely play a significant role in antitumor cytotoxic response through alphaEbeta7-E-cadherin interactions. PMID: 17325197
26. An investigation to evaluate the diagnostic value of the relative number of CD103 expressing CD4(+) T-lymphocytes in the bronchoalveolar lavage fluid of patients with various interstitial lung diseases, including pulmonary sarcoidosis, is reported. PMID: 18182176
27. Integrin alpha(E)(CD103)beta(7) is not only involved in epithelial retention but also in shaping and proper intraepithelial morphogenesis of some leukocytes. PMID: 18492951
28. Phenotypic analysis of peripheral blood and decidual CD8+ T cells showed the presence of activated CD8+ T cells as well as a population of CD8+CD103+ T cells in decidual tissue. PMID: 19150377
29. A higher proportion of CD103+CD4+ T cells and ITGAE -1088 AA genotype might be associated with fibrosis formation in pulmonary sarcoidosis. PMID: 19604725

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HGNC: 6147

OMIM: 604682

KEGG: hsa:3682

STRING: 9606.ENSP00000263087

UniGene: Hs.513867