JMJD1B (Jumonji Domain-Containing 1B), also known as KDM3B, is a histone demethylase enzyme that specifically removes methyl groups from histone H3 lysine 9 (H3K9). The JMJD1B (C69G2) Rabbit mAb targets this protein, enabling researchers to investigate its role in gene expression regulation, cellular differentiation, and cancer biology .
While the provided search results focus primarily on anti-Jo-1 antibodies in autoimmune diseases , data specific to JMJD1B antibody includes:
Mechanistic Insights: JMJD1B demethylates H3K9me2, influencing transcriptional activation and epigenetic reprogramming .
Disease Relevance: Overexpression of JMJD1B is linked to cancer progression, particularly in hormone-dependent tumors .