jmj1 Antibody

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Description

Overview of JMJD1B Antibody

JMJD1B (Jumonji Domain-Containing 1B), also known as KDM3B, is a histone demethylase enzyme that specifically removes methyl groups from histone H3 lysine 9 (H3K9). The JMJD1B (C69G2) Rabbit mAb targets this protein, enabling researchers to investigate its role in gene expression regulation, cellular differentiation, and cancer biology .

Table 2: Clinical and Research Applications

ApplicationUtility in Research
Western BlottingDetects JMJD1B expression in cell lysates .
ImmunofluorescenceLocalizes JMJD1B in nuclear compartments .
CUT&RUNMaps histone modification sites regulated by JMJD1B .

Research Findings

While the provided search results focus primarily on anti-Jo-1 antibodies in autoimmune diseases , data specific to JMJD1B antibody includes:

  • Mechanistic Insights: JMJD1B demethylates H3K9me2, influencing transcriptional activation and epigenetic reprogramming .

  • Disease Relevance: Overexpression of JMJD1B is linked to cancer progression, particularly in hormone-dependent tumors .

Limitations and Considerations

  • Specificity: Validated for human and monkey samples only .

  • Clinical Data: No direct therapeutic applications are reported in the provided sources.

Product Specs

Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Form
Liquid
Lead Time
14-16 week lead time (made-to-order)
Synonyms
jmj1 antibody; SPAC25H1.02 antibody; JmjC domain-containing protein 1 antibody; Jumonji domain-containing protein 1 antibody
Target Names
jmj1
Uniprot No.

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