KAT1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
KAT1; At5g46240; MPL12.2; Potassium channel KAT1
Target Names
KAT1
Uniprot No.
Target Background
Function
KAT1 is a highly selective inward-rectifying potassium channel that plays a crucial role in plant physiology. This voltage-gated channel is responsible for mediating long-term potassium influx into guard cells, which ultimately leads to stomatal opening. The channel operates based on conformational changes, switching between open and closed states in response to voltage differences across the membrane. Activation occurs upon hyperpolarization, and its activity is enhanced under conditions of external acidification. Notably, KAT1 is also permeable to ammonium ions and is effectively blocked by tetraethylammonium and barium ions.
Gene References Into Functions
- Research indicates that in KAT-type K(+) channel KAT1, residue K85 within the linker forms a hydrogen bond with C211. This interaction is essential for pH activation. PMID: 26846460
- The plant stress metabolite acrolein has been shown to inhibit light-induced stomatal opening by inhibiting KAT1 potassium channels in Arabidopsis thaliana. PMID: 25144495
- Mutations in the central Phe residue have been found to promote the closed conformation of KAT1, while mutations affecting the countercharge centers favor the open conformation. PMID: 25185120
- Studies have revealed that the pH-sensor of the plant Kin channel KAT1 is not governed by a single key amino acid but rather by a complex interplay of multiple titratable residues. PMID: 22070190
- Research has demonstrated that trafficking of KAT1 is dependent on ER export signals. PMID: 20712625
- Findings suggest the existence of a kinase analogous to protein kinase C in plant cells. This kinase may modulate KAT1 channel activity through calcium-dependent phosphorylation at specific residues located in the cytosolic region of KAT1. PMID: 20423459
- Phosphatidylinositol phosphates have been identified as crucial regulators for both voltage-dependent and -independent activation of A. thaliana potassium channels expressed in X. laevis oocytes, including KAT1. PMID: 15842627
- When KAT1 was expressed in mammalian HEK293 cells and measured using patch clamp technology in the whole cell configuration, a depletion of extracellular potassium resulted in a decrease in channel conductance. PMID: 16263909
- This research demonstrated that the trafficking of plant plasma membrane ion channels is regulated through a conserved mechanism. PMID: 16950859
- Structure prediction for the down state of the Kat1 voltage sensor has been conducted. PMID: 17187053
- A study reported that the hormone abscisic acid, which plays a crucial role in regulating ion transport and transpiration in plants under water stress, triggers the selective endocytosis of the KAT1 K+ channel protein in epidermal and guard cells. PMID: 17683934
- The combination use of carefully selected detergents enabled the effective purification of functional KAT1 using affinity and gel-filtration chromatography. PMID: 18638455
Database Links
Protein Families
Potassium channel family, Plant (TC 1.A.1.4) subfamily
Subcellular Location
Membrane; Multi-pass membrane protein.
Tissue Specificity
Expressed in guard cells, and in roots.
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