KCNK5 Antibody

1. Mutations in the promoter region of the TWIK-related acid-sensitive K(+) channel 2 (TASK-2) gene did not result in hypertension or primary aldosteronism (PA) during long-term follow-up in healthy participants. Therefore, they do not appear to be a causal factor for PA. PMID: 29293917
2. Our study suggests a novel role for KCNK5 in regulating platelet size and maturity. Additionally, our findings confirm an association between the SH2B3-locus and platelet count. PMID: 28865245
3. In human aldosterone-producing adrenocortical cancer cell lines, roxithromycin inhibited KCNJ5MUT-induced induction of CYP11B2 (encoding aldosterone synthase) expression and aldosterone production. PMID: 28604387
4. HLA-DQB1*06:02 does not appear to be associated with hypoxic ventilatory response or hypercapnic ventilatory response. However, there are point-wise, uncorrected significant associations between two TASK2/KCNK5 variants (rs2815118 and rs150380866) and hypercapnic ventilatory response. PMID: 28045995
5. These results provide further structural and functional insights into the potential pathophysiological effects of this missense variant in TASK-2. PMID: 27228168
6. Results indicate that up-regulated KCNK5 in activated human T cells does not play a volume regulatory role due to decreased Cl- permeability. This suggests that KCNK5 upregulation might play a role in hyperpolarization of the cell membrane, leading to increased Ca2+ influx and proliferation of T cells. PMID: 26909737
7. The potassium channel TASK2 drives human NK-cell proliferation and cytolytic function. PMID: 26140335
8. Mutant genes (CELA1, HSPG2, and KCNK5) in Balkan endemic nephropathy patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, which are closely linked to the process of angiogenesis. PMID: 24949484
9. Lower expression of the TASK-2 channel is a hallmark of aldosterone-producing adenoma causing aldosteronism and is associated with a higher expression of hsa-miR-23 and hsa-miR-34. PMID: 24285684
10. Potassium channels, particularly K2P channels, are expressed and functional in the apical membrane of airway epithelial cells. PMID: 21964404
11. Disease activity in rheumatoid arthritis patients strongly correlates with K(2P)5.1 expression levels in CD4+ T lymphocytes in the peripheral blood. PMID: 21314928
12. 17beta-estradiol induces the expression of KCNK5 via ERalpha(+) in breast cancer cells. This channel plays a role in regulating proliferation in these cell lines. PMID: 21680658
13. Data suggest that the cytokine receptor-coupled JAK/STAT pathway is upstream of the swelling-induced phosphorylation and activation of TASK-2 in Ehrlich ascites tumor cells. PMID: 20631251
14. We have identified and characterized K2P5.1 as a critical player in T-cell effector function. Selective targeting of K(2P)5.1 may hold therapeutic promise for multiple sclerosis and potentially other T-cell-mediated disorders. PMID: 20582984
15. TASK-2 does not possess a histidine residue at the homologous position. Inclusion of such a residue failed to produce the expected increase in pH sensitivity; instead, a slight decrease was observed. PMID: 12634929
16. TASK-2 is not highly expressed in the cerebellum. PMID: 15197476
17. KCNK5 is involved in K(+)-channel activity in regulatory volume decrease in human spermatozoa. Channel activity is regulated beyond the extent of protein expression. PMID: 18157847

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