Function
KCR1 is a beta-ketoacyl-coenzyme A reductase essential for the elongation of fatty acid precursors to sphingolipids, triacylglycerols, cuticular waxes, and suberin. It catalyzes the initial reduction step in very-long-chain fatty acid (VLCFA) biosynthesis. RNA interference (RNAi)-mediated knockdown of KCR1 results in plants exhibiting fused vegetative and reproductive organs, and abnormal trichome, epidermal cell, and root morphology. This phenotype is not complemented by KCR2.
Gene References Into Functions
AtKCR1 is a functional beta-ketoacyl-coenzyme A reductase isoform involved in microsomal fatty acid elongation. [PMID: 19439572](https://www.ncbi.nlm.nih.gov/pubmed/19439572)
Protein Families
Short-chain dehydrogenases/reductases (SDR) family
Subcellular Location
Endoplasmic reticulum membrane; Single-pass membrane protein.
Tissue Specificity
Expressed in green siliques, flowers, inflorescence stems, leaves and roots.