Keap1 Antibody

1. The Nrf2/Keap1 system regulates VSMC apoptosis during neointimal formation, effectively inhibiting neointimal hyperplasia following vascular injury. PMID: 27198574
2. Renal tubular deletion of Keap1 promotes features of nephrogenic diabetes insipidus, confirming that Nrf2 activation within developing tubular cells leads to a water reabsorption defect. PMID: 28233855
3. By inhibiting the binding of Keap1 to Nrf2. PMID: 30021365
4. These studies are the first to demonstrate that brain ischemic preconditioning safeguards the blood-brain barrier against ischemic injury by generating endogenous electrophiles and activating the Nrf2 pathway through the inhibition of Keap1- and GSK3beta-dependent Nrf2 degradation. PMID: 29775963
5. These findings suggest that trehalose functions as a novel activator of the p62-Keap1/Nrf2 pathway, in addition to inducing autophagy. Consequently, trehalose may prove beneficial in treating various chronic diseases characterized by oxidative stress and impaired autophagy. PMID: 29241092
6. While injury tends to suppress these genes in wild-type mice, this suppression is attenuated or reversed in Keap1 hypomorphs, indicating that protection in these mice is mediated by increased Nrf2 transcriptional activity. PMID: 27804998
7. These findings suggest that the Keap1-Nrf2 system plays a critical role in depression, and dietary intake of sulforaphane-rich food during juvenile stages and adolescence can confer stress resilience in adulthood. PMID: 27470577
8. These results indicate that inactivation of KEAP1 protein by epigallocatechin gallate may mediate its function in activating NRF2. PMID: 28457936
9. The incidence, multiplicity, and burden of Cutaneous squamous cell carcinomas that develop in Keap1(flox/flox)/Nrf2(-/-) mice are significantly greater than in their Keap1(flox/flox)/Nrf2(+/+) counterparts, establishing Nrf2 activation as the protective mediator. PMID: 27216826
10. The p62-keap1-Nrf2 antioxidant pathway is primarily activated in the early stage of APAP hepatotoxicity. PMID: 29331651
11. Keap1 deletion in renal tubular cells results in abnormal kidney development consistent with hydronephrosis. PMID: 27484495
12. Serine 351 phosphorylation of p62 does not enhance its binding to Keap1 or stabilize the nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factor in this neuronal context. Notably, Nrf2 protein levels are markedly decreased despite transcriptional activation of the Nrf2 gene. PMID: 28055010
13. These results suggest that the Keap1/Nrf2 axis plays a critical role in NFATc1 expression and osteoclastogenic progression. PMID: 28515152
14. Results demonstrate that Keap1 deficiency in long-term hematopoietic stem cells increases the number of multipotent progenitor cells in steady-state hematopoiesis, while impairing their hematopoietic regeneration capacity. PMID: 28674188
15. During cellular stress or electrolytic imbalance, cysteine residue modification in Keap1 induces the release of Nrf2 from the Nrf2-Keap1 complex, stabilizing Nrf2 and causing its nuclear translocation. PMID: 28045693
16. This study found that under oxidative stress induced by experimental periodontitis, the Nrf2/antioxidant defense pathway is activated and can be visualized from the luciferase activity in the Keap1-dependent oxidative stress detector-luciferase mice model. PMID: 27854327
17. Caffeic acid induces Nrf2 activation by decreasing the expression of its inhibitor protein Keap1 and blocking the binding of Nrf2 with Keap1. PMID: 26721592
18. Hepatocyte-specific deletion of Keap1, triggering constitutive Nrf2 activation, shifts hepatic metabolism towards increased lipid catabolism, reduced liponeogenesis, and activation of the pentose phosphate pathway. PMID: 26698665
19. Findings reveal that Keap1 regulates cell migration by influencing the subcellular localization and activity of cortactin independently of its role in oxidant stress responses. PMID: 26602019
20. Under chronic hyperglycemic conditions, Keap1 inhibition increases Nrf2 nuclear translocation, enhances antioxidant gene expression, and reduces ROS production to normoglycemic levels. PMID: 26647385
21. In conclusion, increased Keap1/Nrf2 signaling in the liver is accompanied by repressed gluconeogenesis and lipogenesis, which may at least partially explain the ameliorated diabetic phenotype in the Keap1-hypo mice. PMID: 26701603
22. Keap1 utilizes multiple cysteine residues specifically and/or collaboratively as sensors for detecting a wide range of environmental stresses. PMID: 26527616
23. Iron deficiency induces the nuclear translocation of Nrf2 via Keap1 degradation by autophagy and subsequently upregulates the expression of HO-1. PMID: 25754743
24. These results strongly suggest that p62 plays a crucial role in preventing fenofibrate-induced cell death. PMID: 26282199
25. A high-fat diet alters short-term glucose homeostasis to a greater degree in Keap-KD mice compared to C57BL/6 mice. PMID: 23507082
26. Keap1 knockdown causes severe disruption in both the redox cycle and the cell cycle of replicating hepatocytes. PMID: 25483186
27. Data confirm a role for GNOM in endoplasmic reticulum (ER)-Golgi trafficking and reveal that a GNL1/GNOM-mediated early secretory pathway selectively regulates PIN1 basal polarity establishment, which is essential for normal plant development. PMID: 24997191
28. Results implicate p62-dependent autophagic degradation of Keap1 by palmitate as a mechanism contributing to hepatocyte lipoapoptosis. PMID: 24769730
29. The data indicate the high degree of selectivity of CDDO-me for the Nrf2:Keap1 signaling pathway. PMID: 24859727
30. Data indicate feedback activation of the kelch-like ECH-associated protein 1 (Keap1)-NF-E2-Related Factor 2 (Nrf2) pathway when the proteasome is impaired. PMID: 25049227
31. Forced expression of WT mKeap1 restored the ability of oxaliplatin to activate the transcription factor. Cys(151) in Keap1 was required for the response stimulated by oxaliplatin. PMID: 24556415
32. Nrf2 activation by Keap1 knockdown attenuates glomerulosclerosis. These results indicate that the Nrf2-Keap1 system is a promising drug target for the treatment of chronic kidney diseases. PMID: 24523358
33. The Keap1-Nrf2 complex prevents oxidative injury in ischemia/reperfusion-stressed orthotopic liver transplantation through Keap1 signaling, which negatively regulates the Nrf2 pathway. PMID: 23867319
34. The bone marrow cells of Keap1-deficient mice showed enhanced granulocyte-monocyte differentiation and lower erythroid and lymphoid, suggesting granulocyte-monocyte lineage priming in Keap1-null HSCs. PMID: 24580727
35. Caloric restriction induced induction of fatty acid oxidation gene expression was augmented with Keap1 knockdown, which was associated with differential expression of several miRNAs implicated in fatty acid oxidation and lipid accumulation. PMID: 23884569
36. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. PMID: 24011591
37. Silencing of Keap1 in macrophages boosts induced transcription of Il-6 via NF-kappaB activation. PMID: 23906629
38. The Keap1/Nrf2 axis regulates RANKL-dependent osteoclastogenesis through modulation of intracellular ROS signaling via expression of cytoprotective enzymes. PMID: 23801334
39. Genetic activation of Nrf2 signaling by Keap1 gene hypomorphic knockdown (Keap1flox/-) markedly suppresses the onset of diabetes. PMID: 23716596
40. This study assigns a novel positive role of Keap1 in upregulating p62-mediated autophagic clearance of ubiquitin aggregates. PMID: 20495340
41. R-alpha-lipoic acid exerts a neuroprotective effect against oxidative stress in retinal neurons in vitro and in vivo by inducing HO-1 through Keap1/Nrf2 signaling. PMID: 23295186
42. The Keap1-C151-dependent mechanism of Nrf2 activation is protective, while p62-mediated activation or somatic mutations leading to persistent or prolonged Nrf2 activation comprise the aspect of Nrf2 that is expected to promote tumor growth and survival. PMID: 23589329
43. The Keap1-Nrf2 system regulates an important defense mechanism against upper aerodigestive tract carcinogenesis. PMID: 23250896
44. This study discovered that the Nrf2/Keap1 pathway detects loss of loricrin and directly upregulates the expression of genes involved in the compensatory response, thus ensuring postnatal survival. PMID: 23237955
45. HFD-induced obesity and lipid accumulation in white adipose tissue were decreased in Keap1-KD mice. PMID: 22936178
46. The autophagy pathway maintains the integrity of the Keap1-Nrf2 system for normal liver function by governing Keap1 turnover. PMID: 22872865
47. Morphological changes in the esophageal epithelium are associated with dynamic changes in gene expression. Nrf2/Keap1 pathway activity is required for the maturation of mouse esophageal epithelium. PMID: 22567161
48. Activation of endogenous intracellular levels of Nrf2 by siRNA knockdown of Keap1 is sufficient to provide protection in models of oxidative stress and Parkinson's disease. PMID: 22342405
49. The p62-Nrf2-Nqo1 cascade functions to ensure mammalian longevity by stabilizing mitochondrial integrity. PMID: 22222206
50. Induction of the antioxidative stress protein Keap1 after cerebral ischemia may represent an important endogenous neuroprotective response. PMID: 21075092

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KEGG: mmu:50868

STRING: 10090.ENSMUSP00000062467

UniGene: Mm.248266