KIF3C Antibody

Functional and Localization Insights

KIF3C is a neuronal kinesin-II motor protein critical for anterograde axonal transport. Key findings from antibody-based studies include:

• Neural Enrichment: KIF3C is predominantly expressed in brain, spinal cord, and retina, with strong immunostaining in cerebellar Purkinje cells and retinal ganglion cells .

• Subcellular Localization: In neurons, KIF3C localizes to cell bodies, dendrites, and axons, often associating with vesicles .

• Heteromeric Complexes: KIF3C forms combinatorial complexes with KIF3A but not KIF3B, suggesting distinct functional roles in cargo transport .

Cancer Biology

KIF3C is implicated in tumor progression and therapy resistance, as demonstrated by:

Neurological Research

• Photoreceptor Cilia: KIF3C-associated pathways regulate connecting cilium disassembly in retinal cells .

• Purkinje Cell Dysfunction: Altered KIF3C expression disrupts FMRP target transcripts in cerebellar neurons .

Performance Across Applications

Cross-Reactivity Notes

• The antibody does not cross-react with KIF3A or KIF3B, confirmed via immunoblots .

• Minor bands in WB may represent splice variants or post-translationally modified forms .