KIN13A Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
KIN13A antibody; KINESIN-13A antibody; At3g16630 antibody; MGL6.9 antibody; Kinesin-like protein KIN-13A antibody; AtKINESIN-13A antibody; AtKIN13A antibody
Target Names
KIN13A
Uniprot No.
Target Background
Function
KIN13A antibody targets an internal motor kinesin protein that is involved in trichome morphogenesis. This protein plays a key role in regulating the formation of Golgi-associated vesicles. Furthermore, it plays a central role in microtubule disassembly through the active ARAC10-ICR5 cascade, which ultimately establishes the secondary cell wall pattern in metaxylem vessel cells. KIN13A works redundantly with KIN13B to modulate cell wall synthesis and cell expansion through the THE1 pathway.
Gene References Into Functions
- Kinesin-13A plays a central role in microtubule disassembly via the active ROP-MIDD1 cascade, which establishes the secondary cell wall pattern in metaxylem vessel cells. PMID: 24280391
- Research has shown that RIP3 is localized at microtubules and interacts with the kinesin-13 family member AtKinesin-13A, suggesting a role for RIP3 in microtubule reorganization and a potential function in ROP-regulated polar growth. PMID: 20832900
- AtKinesin-13A decorates Golgi-associated vesicles and may be involved in regulating the formation of Golgi vesicles in the root-cap peripheral cells. PMID: 19939242
Database Links
Protein Families
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, KIN-13 subfamily
Subcellular Location
Golgi apparatus, Golgi stack. Cytoplasm, cytoskeleton.
Tissue Specificity
Expressed in leaves, roots, young and mature seedlings. Preferentially expressed in the secondary cell wall pits of differentiating metaxylem vessel cells (at the protein level).
Q&A
Kinesin-13A (KIN13A) antibodies are critical tools for studying microtubule dynamics and cellular transport mechanisms. Below are structured FAQs addressing key research challenges and methodologies, informed by experimental approaches from recent studies.
Advanced Research Challenges
Resolving contradictions in KIN13A localization data across studies
Designing assays to study KIN13A-actin interplay
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Dual-channel TIRF microscopy: Simultaneously track KIN13A (antibody-labeled) and LifeAct-tagged actin filaments
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Functional interference: Combine antibody-based inhibition with actin-disrupting drugs (latrunculin A/cytochalasin D)
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Data normalization: Use kymograph analysis to account for cytoskeletal remodeling rates
Methodological Considerations
Integrating KIN13A antibody data with omics datasets
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Cross-platform validation:
Technical Troubleshooting
Addressing non-specific bands in Western blots
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Stepwise refinement:
Quantifying KIN13A dynamics in live-cell imaging
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