KNAT1 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (Made-to-order)
Synonyms
KNAT1 antibody; BP antibody; BP1 antibody; At4g08150 antibody; F9M13.2Homeobox protein knotted-1-like 1 antibody; Protein BREVIPEDICELLUS antibody; Protein KNAT1 antibody
Target Names
KNAT1
Uniprot No.
Target Background
Function
KNAT1 plays a crucial role in meristem function, maintaining cells in an undifferentiated, meristematic state. Its expression ceases upon the shoot apex transition from vegetative to reproductive development. It acts as a positive regulator of LATERAL ORGAN BOUNDARIES (LOB) and likely binds to the 5'-TGAC-3' DNA sequence. Furthermore, it exhibits intercellular mobility between the L1 and L2/L3 meristem layers, potentially via plasmodesmata.
Gene References Into Functions
- Loss-of-function KNOX2 alleles in Arabidopsis result in impaired aerial organ differentiation and highly complex leaves, mirroring the phenotype of gain-of-function KNOX1 alleles. (PMID: 25671434)
- In the cambium, unlike their shoot apical meristem function, KNAT1 and STM promote cell differentiation by repressing BOP genes. (PMID: 25371365)
- The Arabidopsis ASYMMETRIC LEAVES complex interacts with PRC2, recruiting it to BREVIPEDICELLUS and KNAT2 homeobox genes to silence these stem cell regulators in differentiating leaves. (PMID: 23468429)
- KNAT1 negatively regulates root skewing, potentially through auxin transport modulation. (PMID: 23889705)
- KNAT1/BP, but not KNAT2, can substitute for STM in meristem establishment and organization. (PMID: 23573875)
- ATH1-KNAT2 functions redundantly with KNAT6, both negatively regulated by BP during pedicel development. (PMID: 22140242)
- BP/KNAT1 acts as a negative regulator, while KNAT2 and KNAT6 act as positive regulators of floral organ separation within the IDA-HAE/HSL2 signaling cascade. (PMID: 21742991)
- The late-flowering phenotype of as1-1 and as2-1 mutants may result from ectopic expression of the KNAT126 triple mutation. (PMID: 19891706)
- Heterodimers with PENNYWISE or POUND-FOOLISH are essential for early internode patterning. (PMID: 16741748)
- BP and PNY restrict KNAT6 and KNAT2 expression to ensure proper inflorescence development. (PMID: 18390591)
- KNAT1 expression in the integuments causes extra cell divisions in the outer integument layer, compensated by reduced cell volume, highlighting mechanisms controlling ovule integument morphogenesis. (PMID: 18410683)
Database Links
Protein Families
TALE/KNOX homeobox family
Subcellular Location
Nucleus.
Tissue Specificity
Expressed in the vegetative meristem. Present in the base of flower primordia.
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