KRE28 Antibody forms a kinetochore complex with SPC105, which is essential for kinetochore binding by a specific set of kMAPs (BIM1, BIK1 and SLK19) and motors (CIN8, KAR3). It plays a crucial role in kinetochore-microtubule binding and the spindle assembly checkpoint.
Protein Families
KRE28 family
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Chromosome, centromere, kinetochore.
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