LACS1 Antibody
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Product Specs
Buffer
Preservative: 0.03% ProClin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (Made-to-Order)
Synonyms
LACS1 antibody; CER8 antibody; At2g47240 antibody; T8I13.8Long chain acyl-CoA synthetase 1 antibody; EC 6.2.1.3 antibody; Protein ECERIFERUM 8 antibody
Target Names
LACS1
Uniprot No.
Target Background
Function
This antibody targets LACS1, an enzyme involved in the activation of long-chain fatty acids. LACS1 plays a crucial role in both the synthesis of cellular lipids and their degradation via β-oxidation. It participates in both the wax and cutin biosynthetic pathways, exhibiting a preference for palmitate, palmitoleate, linoleate, and eicosenoate. Importantly, LACS1 demonstrates specific activity against very-long-chain fatty acids (VLCFAs) with chain lengths exceeding 24 carbons (C24).
Gene References Into Functions
- In Arabidopsis, the combined inactivation of LACS1 and LACS4 resulted in conditional pollen sterility and impaired wax biosynthesis. (PMID: 21790813)
- LACS1 is localized to the endoplasmic reticulum (ER) and functionally overlaps with LACS9 in providing acyl-CoAs for triacylglycerol (TAG) biosynthesis. (PMID: 21143684)
- lacs1 lacs2 double-mutant plants exhibited pleiotropic phenotypes, including organ fusion, abnormal flower development, and reduced seed set. (PMID: 20237894)
- LACS1 is a novel acyl-CoA synthetase that preferentially modifies both VLCFAs for wax synthesis and long-chain (C16) fatty acids for cutin synthesis. (PMID: 19392700)
Database Links
Protein Families
ATP-dependent AMP-binding enzyme family
Subcellular Location
Endoplasmic reticulum.
Tissue Specificity
Epidermal-specific expression along the entire stem. In cauline leaves, was expressed over the entire leaf surface, most strongly in trichomes and guard cells, but not in mesophyll cells. In flowers, the expression was detected in the stigma and filaments
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