LAMA4 Antibody
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Description
Definition and Target Biology
LAMA4 (laminin alpha 4) is a subunit of laminins, heterotrimeric glycoproteins essential for basement membrane formation and cell adhesion. The LAMA4 antibody specifically binds to this chain, enabling researchers to study its roles in:
Table 1: Functional Insights from LAMA4 Antibody Studies
Mechanistic Insights
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AML Microenvironment: Lama4⁻/⁻ MSCs upregulate inflammatory cytokines (e.g., IL-6, TNF-α) and enhance mitochondrial transfer to leukemic cells, reducing reactive oxygen species (ROS) and promoting chemoresistance .
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Cancer Metastasis: In HCC, LAMA4 localizes to tumor vasculature basement membranes, facilitating angiogenesis and invasive growth .
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Cellular Motility: LAMA4 inhibition disrupts actin cytoskeleton dynamics by altering Rho GTPase-activating proteins (e.g., ARHGAP11A/B) and Parvin A expression, impairing directed migration .
Clinical and Therapeutic Relevance
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Diagnostic Potential: Elevated LAMA4 in HCC tissues vs. healthy liver (0.37 ± 0.25 vs. 0.18 ± 0.12 mRNA levels; P < 0.01) .
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Therapeutic Targeting: Blocking LAMA4 in MSCs sensitizes AML cells to cytarabine by restoring ROS levels .
Limitations and Future Directions
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Species Specificity: Most studies use murine models; human clinical validation remains limited .
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Dual Roles: LAMA4 exhibits context-dependent pro- or anti-tumor effects, necessitating tissue-specific investigations.
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Technical Challenges: Antibody customization (e.g., conjugation) requires optimization for novel applications .
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
We typically dispatch products within 1-3 working days after receiving your orders. Delivery times may vary depending on the purchase method or location. Please consult your local distributors for specific delivery time information.
Synonyms
CMD1JJ antibody; DKFZp686D23145 antibody; LAMA3 antibody; LAMA3, formerly antibody; LAMA4 1 antibody; LAMA4 antibody; LAMA4*-1 antibody; LAMA4_HUMAN antibody; Laminin alpha 4 antibody; Laminin alpha 4 chain antibody; Laminin subunit alpha 4 precursor antibody; Laminin subunit alpha-4 antibody; Laminin-14 subunit alpha antibody; Laminin-8 subunit alpha antibody; Laminin-9 subunit alpha antibody
Target Names
Uniprot No.
Target Background
Function
Laminin, binding to cells through a high affinity receptor, is believed to mediate cell attachment, migration, and organization into tissues during embryonic development. This process occurs by interacting with other extracellular matrix components.
Gene References Into Functions
- Elevated LAMA4 expression is associated with gastric cancer. PMID: 30015861
- Disruption of LAMA4, LAMA5, and LAMB2, or the laminin-receptor interaction, occurs in neuromuscular diseases such as Pierson syndrome and Lambert-Eaton myasthenic syndrome (LEMS). (Review) PMID: 27614294
- Research highlights MCAM and LAMA4 as potential targets for renal cell carcinoma prognosis and treatment. PMID: 26921326
- LAMA4-integrin signaling impacts chondrocyte morphology and gene expression, contributing to cluster formation in osteoarthritic chondrocytes. PMID: 26295200
- LAMA4 expression is reduced in preeclamptic placentas. It promotes trophoblast cell invasion, migration, and angiogenesis. Hypoxia-reoxygenation decreases LAMA4 expression and disrupts the relationship between LAMA4 expression and p38 and ERK activation. PMID: 26059342
- Oxidative stress plays a crucial role in regulating LAMA4 expression through MAPK signaling pathways, suggesting a potential pathological mechanism for pre-eclampsia. PMID: 25676580
- Laminins 411 and 421 differentially promote tumor cell migration through alpha6beta1 integrin and MCAM (CD146). PMID: 24951930
- Data from peptide fragment experiments suggests that laminin alpha4 (and laminin alpha5) may be involved in the host defense response and protect tissues from invading pathogens. PMID: 20433883
- Comparative studies of laminins with alpha1, alpha4, and alpha5 chains have revealed isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. PMID: 12393739
- Research has identified a splice variant of the human laminin alpha4 subunit transcript containing 21 extra nucleotides. PMID: 12445830
- The G domain of the laminin alpha4 chain serves as a specific, high-affinity ligand for alphavbeta3 & alpha3beta1 integrin heterodimers. These integrins, alongside alpha6beta1, collaboratively mediate endothelial cell-alpha4 laminin interaction and blood vessel development. PMID: 12454288
- The alpha4 laminin subunit regulates vascular endothelium cell survival. PMID: 14980521
- The laminin alpha4 LG4 module potentially plays a significant role in cell adhesion and/or vessel wall formation in the skin by interacting with syndecan-2 and/or -4. PMID: 15086543
- Downregulation of laminin alpha4 chain expression inhibits glioma invasion. PMID: 15915502
- Alterations in laminin isoforms are associated with brain tumor invasion and angiogenesis. [review] PMID: 16146715
- Findings suggest that proteins containing the G(1121-1139) peptide may carry out their biological functions through interactions with alphavbeta3 integrin. PMID: 16824487
- Laminin alpha4 chain fragments (Lms) exhibit a de-adhesive function and could thus contribute to detachment, migration, and invasion of renal carcinoma cells in vivo. PMID: 17533363
- Two novel mutations (2828C>T [Pro943Leu] & 3217C>T [Arg1073X]) within the integrin-interacting domain of the LAMA4 gene reduce its integrin binding ability, leading to endothelial cell loss and heart failure. PMID: 17646580
- LAMA4 expression is specifically upregulated at both mRNA and protein levels in hepatocellular carcinoma, suggesting a potential role in hepatocarcinogenesis and tumor progression. PMID: 18084776
- Simultaneous changes occur in laminin- and collagen-binding receptors. Laminin-411 reduces adhesion to laminin-511 and fibronectin, indicating that tumor cells might utilize laminin-411 in their invasive behavior. PMID: 18496706
- LM alpha4 and beta2 play roles in the in vitro migration and in vivo tumorigenicity of prostate cancer cells. PMID: 19048114
Database Links
Involvement In Disease
Cardiomyopathy, dilated 1JJ (CMD1JJ)
Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
Tissue Specificity
In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn t
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