LAT2 Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze-thaw cycles.
Lead Time
Typically, we can ship your orders within 1-3 business days of receipt. Delivery time may vary depending on the purchasing method or location. Please consult your local distributors for specific delivery timelines.
Synonyms
HSPC046 antibody; LAB antibody; LAT2 antibody; Linker for activation of B cells antibody; Linker for activation of B-cells antibody; Linker for activation of T cells family member 2 antibody; Linker for activation of T cells transmembrane adaptor 2 antibody; Linker for activation of T-cells family member 2 antibody; Membrane associated adapter molecule antibody; Membrane-associated adapter molecule antibody; Non T cell activation linker antibody; Non-T-cell activation linker antibody; NTAL_HUMAN antibody; WBSCR 5 antibody; Wbscr15 antibody; Williams Beuren syndrome chromosome region 15 antibody; Williams Beuren syndrome chromosome region 5 antibody; Williams-Beuren syndrome chromosomal region 15 protein antibody; Williams-Beuren syndrome chromosomal region 5 protein antibody; WSCR5 antibody
Target Names
LAT2
Uniprot No.
Target Background
Function
LAT2, also known as NTAL or LAB, is a transmembrane adaptor protein involved in the signaling pathways of various immune cells. In mast cells, LAT2 plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling. Additionally, it may participate in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. LAT2 acts as a crucial link, connecting the activation of these receptors and their associated kinases to downstream intracellular events through the recruitment of GRB2.
Gene References Into Functions
- Overexpression of LAT2 has been associated with poor prognosis in cancer, correlating with tumor grade, proliferative potential, and angiogenesis. It also plays a role in mediating the intracellular transport of anticancer agents. PMID: 28815339
- The AML1/ETO target gene LAT2 interferes with the differentiation of normal hematopoietic precursor cells. PMID: 24456692
- LAT2 serves as an early mediator of the anti-leukemic activity of alkylphospholipids and arsenic trioxide. Consequently, LAT2 holds potential as a therapeutic target for cancer treatment. PMID: 23001822
- NTAL functions as a tumor suppressor, enhancing the proximal signaling of leukemic blasts. ERK, a key downstream molecule, is responsible for the biological effects of TCR signaling. PMID: 22269118
- LAB possesses the ability to modulate signaling pathways in virtually all types of leukocytes. PMID: 20643813
- LAT2 protein (NTAL) participates in the activation of the c-Met-Grb2-ERK-cPLA2 signaling cascade during the early stages of H. pylori infection. PMID: 19879355
- Research suggests that NTAL (non-T cell activation linker) might be a structural and possibly functional homologue of LAT (linker for activation of T cells) in non-T cells. PMID: 12486104
- LAB links BCR engagement to downstream signaling pathways. PMID: 12514734
- LAB is primarily phosphorylated on three membrane-distal tyrosines, Tyr(136), Tyr(193), and Tyr(233). Mutations in these tyrosines disrupt Grb2 binding and LAB function. PMID: 14722116
- LAB resembles a LAT molecule that is unable to bind phospholipase C-gamma1. PMID: 15153499
- The NTAL/LAB is expressed in various immune cells. PMID: 15745852
- NTAL acts as a negative regulator of TNF-alpha and IL-8 production following stimulation via TREM-1. PMID: 17277102
- Findings indicate that NTAL may be differentially utilized by specific receptors for relaying alternative signals, suggesting a greater flexibility in the function of TRAPs than previously understood. PMID: 17993265
- Data demonstrate that natural killer cell immunoreceptor tyrosine-based activation motifs preferentially utilize a signaling cassette regulated by the interplay between LAT and LAB. PMID: 18645037
- Expression of LAT2 in T lineage leukemias separates them into two subgroups with distinct prognoses in response to prednisone therapy in children with acute lymphoblastic leukemia. PMID: 19183565
Database Links
Involvement In Disease
LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
Subcellular Location
Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.
Tissue Specificity
Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
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