LGALS1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (12-14 weeks)
Synonyms
LGALS1 antibody; Galectin-1 antibody; Gal-1 antibody; 14 kDa lectin antibody; Beta-galactoside-binding lectin L-14-I antibody; Galaptin antibody; Lactose-binding lectin 1 antibody; Lectin galactoside-binding soluble 1 antibody; S-Lac lectin 1 antibody
Target Names
LGALS1
Uniprot No.
Target Background
Function
LGALS1 Antibody targets Galectin-1, a lectin known for its binding affinity to beta-galactoside and a wide range of complex carbohydrates. This protein plays a crucial role in regulating cellular processes such as apoptosis, proliferation, and differentiation. It exerts its influence by inhibiting the activity of CD45 protein phosphatase, leading to the phosphorylation of Lyn kinase. Notably, Galectin-1 is a potent inducer of T-cell apoptosis.
Gene References Into Functions
- Research indicates that Galectin-1 and VEGFR-2 are expressed in luteal cells of the corpus luteum during mid-luteal stages. Galectin-1 interacts directly with asparagine-linked glycans (N-glycans) on VEGFR-2 within these cells. PMID: 26155753
- Studies have revealed distinct expression patterns for PIBF, LGALS1, LGALS3, LGALS3BP, and LGALS9 mRNA in the endometrium. PMID: 21610087
- Molecular dynamics simulations have been employed to investigate the binding affinity and specificity of Galectin-1 for eight different beta-galactosyl terminal disaccharides. PMID: 21539798
Database Links
Subcellular Location
Secreted, extracellular space, extracellular matrix. Cytoplasm. Secreted.
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