LGALS7 Antibody
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Description
LGALS7 Antibody Characteristics
LGALS7 antibodies are designed to target the Galectin-7 protein, enabling its detection and functional analysis. Key features include:
Validation and Performance
LGALS7 antibodies are rigorously validated across platforms:
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Western Blot: Detects Galectin-7 at ~14–15 kDa in human skin tissue lysates .
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Immunohistochemistry: Localizes Galectin-7 in cytoplasm and nuclei of cervical cancer tissues .
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Immunocytochemistry: Stains Galectin-7 in HUVEC cells with nuclear counterstaining (DAPI) .
Example Validation Data:
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ab10482 (Abcam): Used at 0.005 µg/ml for WB, showing specificity in epidermal extracts of transgenic mice .
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MAB13391 (R&D Systems): Identifies Galectin-7 in HEK001 keratinocytes and cervical cancer biopsies .
Cancer Biology
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Pro-Tumorigenic Role: Galectin-7 promotes oral squamous cell carcinoma (OSCC) invasiveness by upregulating MMP-2/9 via ERK/JNK pathways .
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Suppressive Role: In prostate cancer, Galectin-7 inhibits metastasis via carbohydrate-recognition domain (CRD)-dependent mechanisms .
Autoimmune Disorders
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Systemic Sclerosis (SSc): Reduced Galectin-7 expression in SSc epidermis correlates with disease severity .
Therapeutic Targeting
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Inhibitor Development: Galectin-7’s role in immunosuppression (e.g., IL-10/TGF-β1 secretion in myeloid cells) highlights its potential as a checkpoint target .
Challenges and Future Directions
Product Specs
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA, and 0.02% sodium azide.
Form
Liquid
Lead Time
Typically, we can ship products within 1-3 business days of receiving your order. Delivery times may vary depending on the purchasing method or location. Please contact your local distributors for specific delivery timeframes.
Synonyms
Gal-7 antibody; GAL7 antibody; Galectin 7B antibody; Galectin-7 antibody; HKL-14 antibody; Human keratinocyte lectin 14 antibody; Keratinocyte lectin 14 antibody; Lectin galactoside binding soluble 7 antibody; Lectin; galactoside binding; soluble; 7B antibody; LEG7_HUMAN antibody; LGALS7 antibody; LGALS7A antibody; LGALS7B antibody; P53 induced protein 1 antibody; p53-induced gene 1 protein antibody; Pi7 antibody; PIG1 antibody; TP53I1 antibody
Target Names
LGALS7
Uniprot No.
Target Background
Function
LGALS7 may be involved in cell-cell and/or cell-matrix interactions crucial for normal growth control. It functions as a pro-apoptotic protein, acting intracellularly upstream of JNK activation and cytochrome c release.
Gene References Into Functions
- Elevated O-linked N-Acetyl-glucosamine (O-GlcNAc) levels contribute to reduced Gal-7 expression in cultured human keratinocytes exposed to high glucose environments. PMID: 28526214
- Our observations revealed a significantly reduced overall survival for cases with high Gal-7 expression and improved survival for Gal-7 negative cases, compared to cases with low Gal-7 expression. PMID: 28594391
- Our findings suggest that evaluating galectin-7 expression could guide post-surgical management for non-metastatic clear cell renal cell carcinoma (ccRCC). PMID: 27259255
- These findings indicate the existence of a positive self-amplification pathway that regulates intracellular gal-7 expression in breast and ovarian cancer cells. PMID: 29117220
- Re-expression of Gal-7 influences the regulation of molecular networks in cervical cancer, impacting various cancer hallmarks such as metabolism, growth control, invasion, and evasion of apoptosis. PMID: 27558259
- Measuring scGal-7 content in tape-stripped samples proved helpful in assessing skin barrier function in dry skin conditions like atopic dermatitis (AD). PMID: 27028525
- Data indicate that the galectin inhibitor specifically binds galectin-7 (hGal-7), disrupts the formation of homodimers, and inhibits the pro-apoptotic activity of hGal-7 on Jurkat T cells. PMID: 26543238
- Galectin-7 regulates keratinocytes proliferation and differentiation through the JNK1 pathway. PMID: 26763438
- Assessment of a carbohydrate-recognition domain (CRD)-defective mutant form of gal-7 (R7S) revealed that its ability to modulate apoptosis is independent of its CRD activity. PMID: 26168167
- Our study validates the clinical significance of gal-7 overexpression in ovarian cancer. PMID: 25277199
- Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells. PMID: 25367122
- Galectin-7 is produced by the premenstrual and menstrual endometrium, accumulating in menstrual fluid and potentially acting as a paracrine factor to facilitate post-menstrual endometrial re-epithelialization. PMID: 24782449
- Understanding how these dendrimeric compounds interact with hGal-7 would aid in the development of new tools to investigate carbohydrate recognition by lectins. PMID: 25367374
- Galectin-7 may serve as a potential predictive marker of chemotherapy and/or radiotherapy resistance in patients with oral squamous cell carcinoma. PMID: 24515895
- Galectin-7 may play a role in amyloidogenesis of primary localized cutaneous amyloidosis. PMID: 25172508
- C/EBPbeta is an important mediator of galectin-7 gene activation in breast cancer cells. PMID: 24789216
- Galectin-7 is produced by endometrial epithelium and is elevated in the endometrium of women with a history of miscarriage. We suggest that galectin-7 facilitates embryo adhesion to the endometrium. Elevated galectin-7 levels may lead to abnormal adhesion. PMID: 24522232
- Galectin-7 may play significant roles in downregulating T lymphocyte function after UVB irradiation. PMID: 24134186
- Galectin-7 exhibits a tumor suppressive function, and the gene is epigenetically modified by DNA methylation and significantly down-regulated in gastric cancer. PMID: 23985992
- We suggest that differences in galectin-7 expression and subcellular and extracellular distribution may be crucial in the pathogenic process of hypertrophic scars. PMID: 23493985
- Galectin-7 could be part of a common pathway utilized by mutant p53 to promote cancer progression. PMID: 23967302
- Our results indicate that lactose binding to human Gal-7 induces long-range effects (minor conformational shifts and changes in structural dynamics) throughout the protein, resulting in stabilization of the dimer state, with evidence for positive cooperativity. PMID: 23376190
- High GAL-7 expression is associated with epithelial ovarian cancer. PMID: 23564797
- Knocking down galectin-7 or S100A9 enhanced tumor cell invasion. PMID: 22864818
- Given that residual cholesteatoma matrix is considered a major cause of cholesteatoma recurrence, staining with galectin-7 during surgery could potentially facilitate complete removal of the residue. PMID: 22377647
- Extracellular superoxide dismutase plays a role not only as a reactive oxygen species scavenger but also as a pro-apoptotic factor via COX-2/galectin-7 pathways in the epidermis. PMID: 22251572
- High-resolution crystal structures of Gal-7 at 1.4 A (a dimer) and its 1.7 A structure in complex with an inhibitor, a sulfur-containing 2-O-benzylphosphate galactoside, represent a potential antineoplastic agent. PMID: 22059385
- Our data suggest that the binding of Galectin 7 to Bcl-2 may represent a novel target for enhancing the intrinsic apoptosis pathway. PMID: 21289092
- Galectin-7 modulates the length of primary cilia and wound repair in polarized kidney epithelial cells. PMID: 21677144
- Our data demonstrate that high levels of galectin-7 expression in breast cancer cells significantly increased their ability to metastasize to lungs and bones, and were restricted to high-grade breast carcinomas. PMID: 20382700
- Proteomics analysis revealed that galectin-7 was highly expressed in esophageal squamous cell carcinoma and could serve as a potential biomarker. PMID: 20546628
- Our data show that the Galectine-7 gene was 8 times up-regulated in bronchial epithelial cells from asthmatic children after RSV infection in vitro and overexpressed in bronchial epithelial cells in asthma in vivo. PMID: 17044979
- Galectin-7 increases the expression of MMP-9 through the p38 MAPK signaling pathway. PMID: 19885589
- GAL7 acts as a negative growth regulator for human neuroblastoma cells. PMID: 13679866
- High levels of galectin 7 expression were associated with rapid recurrence rates in hypopharyngeal cancer. PMID: 16788763
- There was no significant difference in Galectin 7 expression in thyroid tissue in thyroid cancer cases compared to non-cancer cases. PMID: 18418527
- Gal-7 influences differentiation in vivo, without evidence for a role in dissemination in head and neck squamous and basal cell carcinomas. PMID: 19012243
- Abnormal expression of galectin-7 in lymphoma cells is not dependent on p53, but is rather associated with DNA hypomethylation. PMID: 19596268
Database Links
Subcellular Location
Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway.
Tissue Specificity
Mainly expressed in stratified squamous epithelium.
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