LGR4 Antibody, HRP conjugated
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Generally, we can ship your orders within 1-3 business days of receiving them. Delivery times may vary depending on the purchasing method or location. For specific delivery times, please consult your local distributor.
Synonyms
BNMD17 antibody; G protein coupled receptor 48 antibody; G-protein coupled receptor 48 antibody; GPR48 antibody; Leucine-rich repeat-containing G protein-coupled receptor 4 antibody; Leucine-rich repeat-containing G-protein coupled receptor 4 antibody; LGR4 antibody; LGR4_HUMAN antibody
Target Names
Uniprot No.
Target Background
Function
LGR4 is a receptor for R-spondins, playing a key role in potentiating the canonical Wnt signaling pathway. This pathway is crucial for the development of various organs, including the liver, kidney, intestine, bone, reproductive tract, and eye. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3, or RSPO4), LGR4 associates with phosphorylated LRP6 and frizzled receptors activated by extracellular Wnt receptors. This interaction triggers the canonical Wnt signaling pathway, leading to increased expression of target genes. Unlike classical G-protein coupled receptors, LGR4 does not activate heterotrimeric G-proteins to transmit the signal.
LGR4's function as a Wnt signaling pathway activator is essential for organ development. It is also implicated in the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Additionally, LGR4 acts as a regulator of bone formation and remodeling, plays a role in kidney development, and is involved in the development of the anterior segment of the eye. During erythropoiesis, LGR4 is also required.
Interestingly, LGR4 also functions as a negative regulator of innate immunity by inhibiting TLR2/TLR4-associated pattern recognition and proinflammatory cytokine production. It is involved in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP.
LGR4's function as a Wnt signaling pathway activator is essential for organ development. It is also implicated in the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Additionally, LGR4 acts as a regulator of bone formation and remodeling, plays a role in kidney development, and is involved in the development of the anterior segment of the eye. During erythropoiesis, LGR4 is also required.
Interestingly, LGR4 also functions as a negative regulator of innate immunity by inhibiting TLR2/TLR4-associated pattern recognition and proinflammatory cytokine production. It is involved in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP.
Gene References Into Functions
- Loss of LGR4 inhibited RSPO3-regulated osteogenesis and RSPO3-induced ERK1/2 signaling inhibition. PMID: 28220828
- Luciferase reporter assays confirmed that LGR4 is a direct target gene of miR-137, with a potential binding site in the 3'UTR of LGR4. PMID: 29786747
- The host protein leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is essential for VSV and VSV-G pseudotyped lentivirus (VSVG-LV) to infect susceptible cells. PMID: 28842478
- High LGR4 expression is associated with osteoarthritis. PMID: 28777797
- Research suggests that LGR4 is a crucial protein for prostate cancer epithelial-mesenchymal transition and metastasis. LGR4 expression is elevated in human prostate cancer cell lines with metastatic potential. Silencing LGR4 in these cell lines impairs cell migration and invasion without affecting cell proliferation. PMID: 28768769
- LGR4 acts as another receptor for RANKL. It competes with RANK to bind RANKL and suppresses canonical RANK signaling during osteoclast differentiation. PMID: 27064449
- The LGR4 A750T variant is correlated with central obesity-related characteristics in young subjects. PMID: 27925416
- Lgr4 is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt/beta-catenin pathways. PMID: 27693558
- miR-34a gene expression upregulation inhibits ARPE-19 cell proliferation, migration, and adhesion partly by suppressing LGR4 expression. PMID: 27977785
- Lgr4 activates the Jmjd2a/AR signaling pathway to promote interaction between AR and the PSA promoter, causing a reduction in prostate cancer apoptosis and cell cycle arrest. PMID: 27743893
- A mechanistic understanding of RANKL-LGR4 interaction provides new insights into LGR4-mediated RANKL signaling in osteoporosis and other diseases. PMID: 27178473
- miR-218 directly targets LGR4 and modulates the PI3K/Akt and Wnt/beta-catenin pathways in LNCaP-IL-6+ cells. PMID: 26986507
- LGR4 promotes tumorigenesis of prostate cancer via the PI3K/Akt signaling pathway. PMID: 25636507
- Aberrant RSPO3-LGR4 signaling potentially serves as a driving mechanism in the aggressiveness of Keap1-deficient lung ADs. PMID: 25531322
- The LGR4-Rspo1 complex crystal structure reveals divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors. PMID: 25480784
- Research suggests a previously unknown Stat3-LGR4 molecular network, which may control osteosarcoma development and progression. PMID: 24455684
- RSPO-LGR4 not only induces the clearance of RNF43/ZNRF3 to increase Wnt receptor levels but also recruits IQGAP1 into the Wnt signaling complex. PMID: 24639526
- Lgr4, regulating eye, kidney, testis, ovary, and uterine organ development, as well as mental development through genetic and epigenetic surveillance, is a novel candidate gene for the pathogenesis of AGR syndrome. PMID: 24519938
- GPR48 overexpression promotes cancer cell proliferation via activation of Wnt signaling. PMID: 24083742
- Lgr4 overexpression promoted glioma cell proliferation through activation of Wnt signaling. PMID: 24083766
- Upregulation of GPR48 resulted in increased phosphorylation of glycogen synthase kinase 3beta. PMID: 23803691
- A functional low-frequency human LGR4 variant (A750T) has been associated with body mass index in a Chinese obese-versus-control study. PMID: 24212090
- Multi-functional norrin is a ligand for the LGR4 receptor. PMID: 23444378
- The c.376C>T mutation is associated with low BMD and osteoporotic fractures, electrolyte imbalance, late onset of menarche, reduced testosterone levels, and an increased risk of squamous cell carcinoma of the skin and biliary tract cancer. PMID: 23644456
- Lgr4/Gpr48 plays a critical role in modulating the TLR2/4 signaling pathway and represents a potential therapeutic target in TLR2/4-associated septic shock and autoimmune diseases. PMID: 23589304
- R-Spondin potentiates Wnt/beta-catenin signaling through orphan receptors LGR4 and LGR5. PMID: 22815884
- LGR4 and LGR5 bind R-spondins with high affinity and mediate the potentiation of Wnt/beta-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. PMID: 21693646
- GPR48 may play a significant role in the invasiveness and metastasis of carcinoma and could be a potential prognostic marker or therapeutic target. PMID: 17178856
- Testicular efferent ducts in the mutant mouse are dramatically shortened and less convoluted than in the wild-type animal, providing an explanation for the phenotype observed in LGR4KO. PMID: 19301269
- Data show that GPR48 shRNA can effectively inhibit in vitro invasion and in vivo metastasis of HeLa cells. PMID: 19550120
Database Links
Involvement In Disease
Osteoporosis (OSTEOP)
Protein Families
G-protein coupled receptor 1 family
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Tissue Specificity
Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen.
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