LIMK2 (Ab-283) Antibody
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Product Specs
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your orders. Delivery time may vary depending on the chosen shipping method or location. Please consult your local distributor for specific delivery time information.
Synonyms
LIM domain kinase 2 antibody; LIM kinase 2 antibody; LIMK 2 antibody; LIMK-2 antibody; Limk2 antibody; LIMK2_HUMAN antibody
Target Names
Uniprot No.
Target Background
Function
LIMK2, a serine/threonine-protein kinase, plays a crucial role in regulating actin filament dynamics. It operates downstream of various Rho family GTPase signal transduction pathways. LIMK2 is involved in astral microtubule organization and mitotic spindle orientation during the early stages of mitosis by phosphorylating TPPP. In vitro, it demonstrates serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP). LIMK2 suppresses ciliogenesis through multiple pathways, including phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and facilitation of YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1.
Gene References Into Functions
- Elevated LIMK2 expression is associated with alcoholic hepatitis. PMID: 28818508
- Research suggests that TUG1 mediates cell growth and chemoresistance of SCLC by regulating LIMK2b via EZH2. PMID: 28069000
- LIMK2 (rs149034313) is associated with Behcet's disease. The LIMK2 association is a missense variant with predicted protein damage that may influence functional interactions with proteins involved in cytoskeletal regulation by Rho GTPase, inflammation mediated by chemokine and cytokine signaling pathways, T cell activation, and angiogenesis. PMID: 26662719
- Studies have observed marked increases in LIM kinase 2 (LIMK2) and cofilin 1 (CFL1) gene expressions in metabolic syndrome patients. PMID: 26956845
- Research indicates that LIMK2 messenger RNA levels were significantly upregulated in subjects with schizophrenia in laminar and cellular samples. PMID: 25981171
- LIMK2, an actin remodeling factor, is a key player in the ciliogenesis control network where YAP/TAZ and directional vesicle trafficking are integral components. PMID: 25849865
- Findings highlight the potential of combining specific LIMK2 inhibitors with anticancer drugs for the treatment of multi-drug resistant cancers. PMID: 23991158
- LIMK2 expression was reduced in intestinal tumors of cancer-prone mice and in human colorectal cancer cell lines and tumors. LIMK2 expression progressively decreased with advancing stages of colorectal cancer. PMID: 23585469
- Overexpression of LIMK2 is associated with breast cancer growth and invasiveness. PMID: 23239465
- The interaction and inhibition of Nf1/LIMK2 directly connects neurofibromatosis type I to actin cytoskeleton remodeling. PMID: 23082153
- LIMK2 is a key regulator that acts through different substrates to provide functional links between the actin cytoskeleton and spindle dynamics. PMID: 22328514
- LIMK2 positively regulates the level of Aurora A, engaging in a positive-feedback loop, and promoting Aurora-A-mediated oncogenic pathways. PMID: 22492986
- LIMK2 variant isoforms were found to be regulated by p53 through direct interaction with regulatory elements within the LIMK2 gene. PMID: 21079653
- Research identified a novel pathway whereby LIMK2b, acting downstream of p53, ensures proper execution of checkpoint arrest by modulating the dynamics of actin polymerization. PMID: 20190821
- A novel pathway emanating from the TGF-beta type I receptor leads to regulation of actin assembly, via the kinase LIMK2. PMID: 15647284
- PKC-mediated exclusion of LIMK2 from the nucleus might be a mechanism to relieve suppression of cyclin D1 expression by LIMK2. PMID: 15923181
- LIMK2 may play a role distinct from LIMK1 in regulating mitotic spindle organization, chromosome segregation, and cytokinesis during the cell division cycle. PMID: 16455074
- Analysis focused on phosphorylation-dependent regulation of unique nuclear and nucleolar localization signals of LIM kinase 2 in endothelial cells. PMID: 16820362
- Research observed a direct interaction between ROCK1 and LIMK2 in polarized, but not blebbing, cells. These findings suggest a specific role for the ROCK1:LIMK2 pathway in mesenchymal-mode migration. PMID: 18852895
Database Links
Protein Families
Protein kinase superfamily, TKL Ser/Thr protein kinase family
Subcellular Location
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.; [Isoform LIMK2a]: Cytoplasm. Nucleus.; [Isoform LIMK2b]: Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
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